Multifunctional nanozyme-reinforced copper-coordination polymer nanoparticles for drug-resistance bacteria extinction and diabetic wound healing

Zhao, Jiahui1,2,3; Xu, Tengfei1,2,4; Sun, Jichao1,2; Yuan, Haitao1,2,3; Hou, Mengyun1,2; Li, Zhijie1,2; Wang, Jigang1,2,5,6; Liang, Zhen1,2

2023-09-18

10.1186/s40824-023-00429-z

BIOMATERIALS RESEARCH   影响因子和分区

1226-4601

2055-7124

BackgroundDrug-resistant bacterial infections in chronic wounds are a persistent issue, as they are resistant to antibiotics and can cause excessive inflammation due to generation of reactive oxygen species (ROS). An effective solution would be to not only combat bacterial infections but also scavenge ROS to relieve inflammation at the wound site. Scaffolds with antioxidant properties are attractive for their ability to scavenge ROS, and there is medical demand in developing antioxidant enzyme-mimicking nanomaterials for wound healing.MethodsIn this study, we fabricated copper-coordination polymer nanoparticles (Cu-CPNs) through a self-assembly process. Furthermore, & epsilon;-polylysine (EPL), an antibacterial and cationic polymer, was integrated into the Cu-CPNs structure through a simple one-pot self-assembly process without sacrificing the glutathione peroxidase (GPx) and superoxide dismutase (SOD)-mimicking activity of Cu-CPNs.ResultsThe resulting Cu-CPNs exhibit excellent antioxidant propertiesin mimicking the activity of glutathione peroxidase and superoxide dismutase and allowing them to effectively scavenge harmful ROS produced in wound sites. The in vitro experiments showed that the resulting Cu-CPNs@EPL complex have superior antioxidant properties and antibacterial effects. Bacterial metabolic analysis revealed that the complex mainly affects the cell membrane integrity and nucleic acid synthesis that leads to bacterial death.ConclusionsThe Cu-CPNs@EPL complex has impressive antioxidant properties and antibacterial effects, making it a promising solution for treating drug-resistant bacterial infections in chronic wounds. The complex's ability to neutralize multiple ROS and reduce ROS-induced inflammation can help relieve inflammation at the wound site.Graphical AbstractSchematic illustration of the ROS scavenging and bacteriostatic function induced by Cu-CPNs@EPL nanozyme in the treatment of MRSA-infected wounds.

Copper-coordination polymer nanoparticles Reactive oxygen species Nanozyme Anti-inflammation Anti-bacteria

SCI

英语

第一 ; 通讯

Engineering ; Materials Science

Engineering, Biomedical ; Materials Science, Biomaterials

WOS:001069963200002

SPRINGERNATURE

Web of Science

1.Southern Univ Sci & Technol, Jinan Univ, Shenzhen Peoples Hosp, Affiliated Hosp 1,Clin Med Coll 2,Dept Geriatr, Shenzhen 518020, Guangdong, Peoples R China
2.Southern Univ Sci & Technol, Jinan Univ, Shenzhen Peoples Hosp, Affiliated Hosp 1,,Clin Med Coll 2,Shenzhen Clin R, R China, Shenzhen 518020, Guangdong, Peoples R China
3.Jinan Univ, Integrated Chinese & Western Med Postdoctoral Res, Guangzhou 510632, Peoples R China
4.Zhejiang Univ, Coll Pharmaceut Sci, Hangzhou 310058, Peoples R China
5.China Acad Chinese Med Sci, Artemisinin Res Ctr, State Key Lab Qual Ensurance & Sustainable Use Dao, Beijing, Peoples R China
6.China Acad Chinese Med Sci, Inst Chinese Mat Med, Beijing, Peoples R China

Zhao, Jiahui,Xu, Tengfei,Sun, Jichao,et al. Multifunctional nanozyme-reinforced copper-coordination polymer nanoparticles for drug-resistance bacteria extinction and diabetic wound healing[J]. BIOMATERIALS RESEARCH,2023,27(1).

Zhao, Jiahui.,Xu, Tengfei.,Sun, Jichao.,Yuan, Haitao.,Hou, Mengyun.,...&Liang, Zhen.(2023).Multifunctional nanozyme-reinforced copper-coordination polymer nanoparticles for drug-resistance bacteria extinction and diabetic wound healing.BIOMATERIALS RESEARCH,27(1).

Zhao, Jiahui,et al."Multifunctional nanozyme-reinforced copper-coordination polymer nanoparticles for drug-resistance bacteria extinction and diabetic wound healing".BIOMATERIALS RESEARCH 27.1(2023).