The effect of intravenous lidocaine on postoperative cognitive dysfunction: a systematic review and meta-analysis

Geng, Chuan1; Hu, Baoji2; Jiang, Jihong3; Zhang, Yunhe4; Tang, Weiqing2; Pan, Mengzhi2; Sun, Leilei2; Chen, Peifen5; Wang, Hengyue6

2023-09-05

10.1186/s12871-023-02202-0

BMC ANESTHESIOLOGY   影响因子和分区

1471-2253

Background Postoperative cognitive dysfunction (POCD) has been reported as a significant complication in elderly patients. Various methods have been proposed for reducing the incidence and severity of POCD. Intravenous lidocaine administration has been reported in the literature to reduce POCD, but the effect of lidocaine remains controversial. Methods We screened Medline, Embase, Cochrane Library, and China National Knowledge Infrastructure (up to April 2022) databases following a search strategy for intravenous lidocaine on POCD. We also screened related bibliographies on lidocaine for POCD. Ten articles comprising 1517 patients were selected and analyzed. We divided the postoperative follow-up period as follows: short term (< 30 days), medium term (30-90 days), and long term (> 90 days). Outcomes We found that lidocaine could attenuate the overall incidence of POCD, especially in the short term. There were no differences between lidocaine and placebo on the overall severity of POCD. Conclusion Lidocaine administered intravenously could attenuate the overall incidence of POCD and its severity in the short term.

Lidocaine Postoperative cognitive dysfunction Meta-analysis Intravenous Elderly

SCI

英语

通讯

NSFC[81701885] ; talent training program[PJ202002]

Anesthesiology

Anesthesiology

WOS:001062192700003

BMC

Web of Science

1.Fengxian Peoples Hosp, Dept Gastroenterol, Xuzhou 221700, Jiangsu, Peoples R China
2.Fudan Univ, Shanghai Pudong Hosp, Pudong Med Ctr, Dept Anesthesiol, Shanghai 201399, Peoples R China
3.Shanghai Jiao Tong Univ, Shanghai Gen Hosp, Sch Med, Dept Anesthesiol, Shanghai 200080, Peoples R China
4.Tongji Univ, Shanghai East Hosp, Sch Med, Dept Ctr ICU, Shanghai 200085, Peoples R China
5.Southern Univ Sci & Technol, Peoples Hosp Shenzhen 3, Affiliated Hosp 2, Dept Resp Dis, Shenzhen 518112, Guangdong, Peoples R China
6.Naval Med Univ, Changhai Hosp, Fac Anesthesiol, Shanghai 200433, Peoples R China

Geng, Chuan,Hu, Baoji,Jiang, Jihong,et al. The effect of intravenous lidocaine on postoperative cognitive dysfunction: a systematic review and meta-analysis[J]. BMC ANESTHESIOLOGY,2023,23(1).

Geng, Chuan.,Hu, Baoji.,Jiang, Jihong.,Zhang, Yunhe.,Tang, Weiqing.,...&Wang, Hengyue.(2023).The effect of intravenous lidocaine on postoperative cognitive dysfunction: a systematic review and meta-analysis.BMC ANESTHESIOLOGY,23(1).

Geng, Chuan,et al."The effect of intravenous lidocaine on postoperative cognitive dysfunction: a systematic review and meta-analysis".BMC ANESTHESIOLOGY 23.1(2023).