Targeted therapy using engineered extracellular vesicles: principles and strategies for membrane modification

Liu, Qisong1,2; Li, Defeng3; Pan, Xiaohua2; Liang, Yujie2,4

2023-09-16

10.1186/s12951-023-02081-0

JOURNAL OF NANOBIOTECHNOLOGY   影响因子和分区

1477-3155

Extracellular vesicles (EVs) are 30-150 nm membrane-bound vesicles naturally secreted by cells and play important roles in intercellular communication by delivering regulatory molecules such as proteins, lipids, nucleic acids and metabolites to recipient cells. As natural nano-carriers, EVs possess desirable properties such as high biocompatibility, biological barrier permeability, low toxicity, and low immunogenicity, making them potential therapeutic delivery vehicles. EVs derived from specific cells have inherent targeting capacity towards specific cell types, which is yet not satisfactory enough for targeted therapy development and needs to be improved. Surface modifications endow EVs with targeting abilities, significantly improving their therapeutic efficiency. Herein, we first briefly introduce the biogenesis, composition, uptake and function of EVs, and review the cargo loading approaches for EVs. Then, we summarize the recent advances in surface engineering strategies of EVs, focusing on the applications of engineered EVs for targeted therapy. Altogether, EVs hold great promise for targeted delivery of various cargos, and targeted modifications show promising effects on multiple diseases.

Exosome Extracellular vesicles Surface modification Targeted delivery

SCI ; EI

英语

第一

Sanming Project of medicine in Shenzhen[SZSM202106019] ; Science and Technology Innovation Committee of Shenzhen["JCYJ20190809113815103","JCYJ20210324113401003","GJHZ20190820115203714","JSGG20191129094218565","KCXFZ2021102016454300"] ; Guangdong Basic and Applied Basic Research Foundation["2023A1515011936","2021A1515220134","2020A1515011107"] ; Shenzhen Clinical Research Center for Mental Disorders[20210617155253001] ; Shenzhen Fund for Guangdong Provincial High Level Clinical Key Specialties[SZGSP013] ; Shenzhen Key Medical Discipline Construction Fund[SZXK042]

Biotechnology & Applied Microbiology ; Science & Technology - Other Topics

Biotechnology & Applied Microbiology ; Nanoscience & Nanotechnology

WOS:001067814900002

BMC

20233814744987

Biocompatibility ; Cytology ; Metabolites ; Nucleic acids

Biological Materials and Tissue Engineering:461.2 ; Biology:461.9 ; Immunology:461.9.1 ; Biochemistry:801.2 ; Organic Compounds:804.1

BIOLOGY & BIOCHEMISTRY

2-s2.0-85170492782

Web of Science

1.Southern Univ Sci & Technol, Shenzhen Peoples Hosp 3, Natl Clin Res Ctr Infect Dis, Shenzhen, Peoples R China
2.Shenzhen Univ, Affiliated Hosp 2, Peoples Hosp Shenzhen Baoan Dist, Dept Orthopaed, Shenzhen 518000, Peoples R China
3.Jinan Univ, Southern Univ Sci & Technol, Shenzhen Peoples Hosp, Affiliated Hosp 1,Dept Gastroenterol,Clin Med Coll, Shenzhen 518020, Peoples R China
4.Shenzhen Mental Hlth Ctr, Shenzhen Inst Mental Hlth, Shenzhen Clin Res Ctr Mental Disorders, Dept Child & Adolescent Psychiat,Shenzhen Kangning, Shenzhen 518020, Guangdong, Peoples R China

Liu, Qisong,Li, Defeng,Pan, Xiaohua,et al. Targeted therapy using engineered extracellular vesicles: principles and strategies for membrane modification[J]. JOURNAL OF NANOBIOTECHNOLOGY,2023,21(1).

Liu, Qisong,Li, Defeng,Pan, Xiaohua,&Liang, Yujie.(2023).Targeted therapy using engineered extracellular vesicles: principles and strategies for membrane modification.JOURNAL OF NANOBIOTECHNOLOGY,21(1).

Liu, Qisong,et al."Targeted therapy using engineered extracellular vesicles: principles and strategies for membrane modification".JOURNAL OF NANOBIOTECHNOLOGY 21.1(2023).