Association between periodontal diseases and chronic obstructive pulmonary disease: Evidence from sequential cross-sectional and prospective cohort studies based on UK Biobank

Wang, Dongyun1; Dai, Liang2; Cui, Zhengqian3; Xing, Weili4; Huang, Xiaoyan2; Yang, Hongyu1,6; Shan, Ying5

2023-10-01

10.1111/jcpe.13890

JOURNAL OF CLINICAL PERIODONTOLOGY   影响因子和分区

0303-6979

1600-051X

Aim To investigate the association between periodontal diseases, airflow limitation and incident chronic obstructive pulmonary disease (COPD) in a large-scale prospective UK Biobank cohort.Materials and Methods Our approach comprised a cross-sectional study and a prospective cohort. Periodontal diseases were determined based on the participants' self-reported dental symptoms, including painful gums, bleeding gums and loose teeth. Logistic regression and Cox proportional hazards models were used to evaluate the association of periodontal diseases with airflow limitation and incident COPD in the cross-sectional study and the prospective cohort, respectively.Results The cross-sectional study involved 495,610 participants. Multivariable analysis found that periodontal diseases were significantly associated with airflow limitation (odds ratio = 1.036, 95% confidence interval [CI]: 1.015-1.059). The cohort study included 379,266 participants with a median follow-up period of 12.68 years. An elevated risk of incident COPD was associated with the presence of periodontal diseases (hazard ratio: 1.248, 95% CI: 1.174-1.326). The effect was consistent among subgroups, including baseline age (<= 65 or >65 years), sex, smoking status and diabetes mellitus.Conclusions Periodontal diseases are associated with airflow limitation and elevated COPD incidence. Maintaining good periodontal health in patients with chronic bronchitis and emphysema may help prevent the onset of COPD.

airflow limitation chronic obstructive pulmonary disease periodontal diseases risk factor UK Biobank

SCI

英语

其他

This work was supported by the National Natural Science Foundation of China (No. 82204148), the Shenzhen Science and Technology Innovation Commission Scientific Research Fund Project (No. JCYJ20220531094401003), the General Program for Clinical Research at[82204148] ; National Natural Science Foundation of China[JCYJ20220531094401003] ; Shenzhen Science and Technology Innovation Commission Scientific Research Fund Project[LCYJ2021025] ; General Program for Clinical Research at Peking University Shenzhen Hospital[KYQD2022203] ; Scientific Research Foundation of Peking University Shenzhen Hospital[20210617170745001] ; Shenzhen Clinical Center for Oral Diseases[SZSM201612061]

Dentistry, Oral Surgery & Medicine

Dentistry, Oral Surgery & Medicine

WOS:001085327100001

WILEY

CLINICAL MEDICINE

2-s2.0-85174290676

Web of Science

1.Peking Univ, Shenzhen Hosp, Stomatol Ctr, Shenzhen, Peoples R China
2.Peking Univ, Shenzhen Hosp, Clin Res Acad, Shenzhen, Peoples R China
3.Southern Univ Sci & Technol, Dept Stat & Data Sci, Shenzhen, Peoples R China
4.Distinct Hlth Care, Internal Med, Guangzhou, Peoples R China
5.Peking Univ, Clin Res Acad, Shenzhen Hosp, 1120 Lianhua Rd, Shenzhen 518036, Guangdong, Peoples R China
6.Peking Univ, Shenzhen Hosp, Stomatol Ctr, 1120 Lianhua Rd, Shenzhen 518036, Guangdong, Peoples R China

Wang, Dongyun,Dai, Liang,Cui, Zhengqian,et al. Association between periodontal diseases and chronic obstructive pulmonary disease: Evidence from sequential cross-sectional and prospective cohort studies based on UK Biobank[J]. JOURNAL OF CLINICAL PERIODONTOLOGY,2023,51(1):97-107.

Wang, Dongyun.,Dai, Liang.,Cui, Zhengqian.,Xing, Weili.,Huang, Xiaoyan.,...&Shan, Ying.(2023).Association between periodontal diseases and chronic obstructive pulmonary disease: Evidence from sequential cross-sectional and prospective cohort studies based on UK Biobank.JOURNAL OF CLINICAL PERIODONTOLOGY,51(1),97-107.

Wang, Dongyun,et al."Association between periodontal diseases and chronic obstructive pulmonary disease: Evidence from sequential cross-sectional and prospective cohort studies based on UK Biobank".JOURNAL OF CLINICAL PERIODONTOLOGY 51.1(2023):97-107.