NOD-like Receptor Signaling Pathway in Gastrointestinal Inflammatory Diseases and Cancers

Zhou, Yujie1; Yu, Songyan1; Zhang, Wenyong1,2

2023-10-01

10.3390/ijms241914511

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES   影响因子和分区

1661-6596

1422-0067

Nucleotide-binding and oligomerization domain (NOD)-like receptors (NLRs) are intracellular proteins with a central role in innate and adaptive immunity. As a member of pattern recognition receptors (PRRs), NLRs sense specific pathogen-associated molecular patterns, trigger numerous signaling pathways and lead to the secretion of various cytokines. In recent years, cumulative studies have revealed the significant impacts of NLRs in gastrointestinal (GI) inflammatory diseases and cancers. Deciphering the role and molecular mechanism of the NLR signaling pathways may provide new opportunities for the development of therapeutic strategies related to GI inflammatory diseases and GI cancers. This review presents the structures and signaling pathways of NLRs, summarizes the recent advances regarding NLR signaling in GI inflammatory diseases and GI cancers and describes comprehensive therapeutic strategies based on this signaling pathway.

NOD-like receptor gastrointestinal inflammatory diseases esophageal cancer gastric cancer colorectal cancer

SCI

英语

第一 ; 通讯

Special Funds for the Cultivation of Guangdong College Students' Scientific and Technological Innovation[pdjh202023c21804]

Biochemistry & Molecular Biology ; Chemistry

Biochemistry & Molecular Biology ; Chemistry, Multidisciplinary

WOS:001082973800001

MDPI

CHEMISTRY

Web of Science

1.Southern Univ Sci & Technol, Sch Med, Shenzhen 518055, Peoples R China
2.Southern Univ Sci & Technol, Key Univ Lab Metab & Hlth Guangdong, Shenzhen 518055, Peoples R China

Zhou, Yujie,Yu, Songyan,Zhang, Wenyong. NOD-like Receptor Signaling Pathway in Gastrointestinal Inflammatory Diseases and Cancers[J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2023,24(19).

Zhou, Yujie,Yu, Songyan,&Zhang, Wenyong.(2023).NOD-like Receptor Signaling Pathway in Gastrointestinal Inflammatory Diseases and Cancers.INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,24(19).

Zhou, Yujie,et al."NOD-like Receptor Signaling Pathway in Gastrointestinal Inflammatory Diseases and Cancers".INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 24.19(2023).