Design and fabrication of biomimicking radially graded scaffolds via digital light processing 3D printing for bone regeneration

Wang, Yue1,2; Chen, Shangsi2; Liang, Haowen1; Bai, Jiaming1; Wang, Min2

2023-10-25

10.1039/d3tb01573d

JOURNAL OF MATERIALS CHEMISTRY B   影响因子和分区

2050-750X

2050-7518

Scaffolds are an essential component in bone tissue engineering (BTE). However, most of the current BTE scaffolds are homogeneous structures and do not resemble the graded architectures of native bone. In the current study, four types of biomimicking scaffold designs based on gyroid (G) and primitive (P) units with radially graded pore sizes were devised, and scaffolds of these designs with two porosity groups (65 vol% and 75 vol%) were fabricated via digital light processing (DLP) 3D printing using biphasic calcium phosphate (BCP). Scaffolds of the gyroid-gyroid (G-G) design displayed better dimensional accuracy, compressive property, and cell proliferation rate than gyroid-primitive (G-P), primitive-gyroid (P-G), and primitive-primitive (P-P) scaffolds. Subsequently, graded G-G scaffolds with different porosities were fabricated and the relationship between compressive strength and porosity was determined. Furthermore, the sintered BCP bioceramics fabricated via current manufacturing process exhibited excellent biocompatibility and bioactivity, indicating their high potential for BTE.

SCI ; EI

英语

第一 ; 通讯

Southern University of Science and Technology (SUSTech)[2022YFE0197100] ; National Key Ramp;D Program of China["GJHZ20200731095606021","KQTD20190929172505711"] ; Shenzhen Science and Technology Innovation Commission["17200519","17202921","17201622","N_HKU749/22"]

Materials Science

Materials Science, Biomaterials

WOS:001082329300001

ROYAL SOC CHEMISTRY

20234414988640

Bioceramics ; Biocompatibility ; Bone ; Calcium phosphate ; Cell proliferation ; Compressive strength ; Fabrication ; Pore size ; Scaffolds (biology)

Biomedical Engineering:461.1 ; Biological Materials and Tissue Engineering:461.2 ; Biology:461.9 ; Immunology:461.9.1 ; Biomaterials (including synthetics):462.5 ; Minerals:482.2 ; Printing Equipment:745.1.1 ; Inorganic Compounds:804.2 ; Ceramics:812.1 ; Physical Properties of Gases, Liquids and Solids:931.2 ; Materials Science:951

Web of Science

1.Southern Univ Sci & Technol, Dept Mech & Energy Engn, Shenzhen 518055, Peoples R China
2.Univ Hong Kong, Dept Mech Engn, Pokfulam Rd, Hong Kong, Peoples R China

Wang, Yue,Chen, Shangsi,Liang, Haowen,et al. Design and fabrication of biomimicking radially graded scaffolds via digital light processing 3D printing for bone regeneration[J]. JOURNAL OF MATERIALS CHEMISTRY B,2023,11(41):9961-9974.

Wang, Yue,Chen, Shangsi,Liang, Haowen,Bai, Jiaming,&Wang, Min.(2023).Design and fabrication of biomimicking radially graded scaffolds via digital light processing 3D printing for bone regeneration.JOURNAL OF MATERIALS CHEMISTRY B,11(41),9961-9974.

Wang, Yue,et al."Design and fabrication of biomimicking radially graded scaffolds via digital light processing 3D printing for bone regeneration".JOURNAL OF MATERIALS CHEMISTRY B 11.41(2023):9961-9974.