南方科技大学知识苑(SUSTech KC): Efficacy of different durations of antifungal prophylaxis with nebulized amphotericin B after lung transplantation: a retrospective cohort study

题名	Efficacy of different durations of antifungal prophylaxis with nebulized amphotericin B after lung transplantation: a retrospective cohort study
作者	Ju, Chunrong 1; Lian, Qiaoyan 1; Wang, Xiaohua 1; Wang, Lulin 1; Zhang, Jianheng 1; Cai, Yuhang 1; Xu, Xin 1; Chen, Rongchang 2,3,5,6; He, Jianxing 1,4
通讯作者	Chen, Rongchang; He, Jianxing
发表日期	2023-09-01
DOI	10.21037/jtd-23-601
发表期刊	JOURNAL OF THORACIC DISEASE 影响因子和分区
ISSN	2072-1439
EISSN	2077-6624
摘要	Background: Nebulized amphotericin B (NAB) is recommended for preventing invasive fungal diseases (IFDs) after lung transplantation. However, the optimal duration of NAB treatment is still unknown. This study aimed to compare the effectiveness of three different durations of antifungal prophylaxis with NAB after lung transplantation: a prolonged course beyond post-transplant 3 months, a medium course of 2 weeks to 3 months, and a short course of less than 2 weeks.Methods: This a single-center retrospective cohort study analyzed 333 patients who underwent lung or heart-lung transplantation between January 2015 and November 2021.Results: A prolonged course of NAB treatment was associated with a significantly lower incidence of IFDs (12.6%) at 1 year post-transplant compared with a short (50.9%) or a medium course (28.0%) (P<0.001). There was no significant difference in the rates of adverse effects among the three durations of NAB treatment (P>0.05). A prolonged course of NAB treatment was associated with a significantly higher 1-year survival rate (94.7%) compared with a short (36.8%) or a medium course (72.0%) (P<0.001).Conclusions: A prolonged course of NAB treatment provided better protection against IFDs than a short or medium course after lung transplantation. Prolonged use of NAB did not significantly increase the incidence of adverse effects.
关键词	Aspergillosis invasive fungal infections lung transplantation nebulized amphotericin B (NAB) prophylaxis
相关链接	[来源记录]
收录类别	SCI
语种	英语
学校署名	通讯
资助项目	State Key Laboratory of Respiratory Disease[SKLRHQN20205] ; Zhongnanshan Medical Foundation of Guangdong Province[ZNSA-2020013] ; Guangzhou Institute of Respiratory Health[2019GIRHZ04]
WOS研究方向	Respiratory System
WOS类目	Respiratory System
WOS记录号	WOS:001081850600001
出版者	AME PUBLISHING COMPANY
来源库	Web of Science
引用统计
成果类型	期刊论文
条目标识符	http://sustech.caswiz.com/handle/2SGJ60CL/582947
专题	南方科技大学第一附属医院
作者单位	1.Guangzhou Med Univ, Affiliated Hosp 1, Guangzhou Inst Resp Hlth, Natl Clin Res Ctr Resp Dis,State Key Lab Resp Dis, Guangzhou, Peoples R China 2.South Univ Sci & Technol, Affiliated Hosp 1, Shenzhen Peoples Hosp, Shenzhen Inst Resp Dis, Shenzhen, Peoples R China 3.Jinan Univ, Affiliated Hosp 2, Shenzhen, Peoples R China 4.Guangzhou Med Univ, Affiliated Hosp 1, Guangzhou Inst Resp Hlth, Natl Clin Res Ctr Resp Dis,State Key Lab Resp Dis, Yanjiang Rd, Guangzhou 510120, Peoples R China 5.South Univ Sci & Technol, Affiliated Hosp 1, Shenzhen Peoples Hosp, Shenzhen Inst Resp Dis, East Shennan Rd, Shenzhen 518020, Peoples R China 6.Jinan Univ, Affiliated Hosp 2, East Shennan Rd, Shenzhen 518020, Peoples R China
通讯作者单位	南方科技大学第一附属医院
推荐引用方式 GB/T 7714	Ju, Chunrong,Lian, Qiaoyan,Wang, Xiaohua,et al. Efficacy of different durations of antifungal prophylaxis with nebulized amphotericin B after lung transplantation: a retrospective cohort study[J]. JOURNAL OF THORACIC DISEASE,2023.
APA	Ju, Chunrong.,Lian, Qiaoyan.,Wang, Xiaohua.,Wang, Lulin.,Zhang, Jianheng.,...&He, Jianxing.(2023).Efficacy of different durations of antifungal prophylaxis with nebulized amphotericin B after lung transplantation: a retrospective cohort study.JOURNAL OF THORACIC DISEASE.
MLA	Ju, Chunrong,et al."Efficacy of different durations of antifungal prophylaxis with nebulized amphotericin B after lung transplantation: a retrospective cohort study".JOURNAL OF THORACIC DISEASE (2023).