Photoacoustic micro-viscoelastography for mapping mechanocellular properties

Yang, Fen1,2,3; Chen, Wei1; Chen, Zhongjiang4

2023-10-01

10.1002/jbio.202300262

JOURNAL OF BIOPHOTONICS   影响因子和分区

1864-063X

1864-0648

Cellular biomechanical properties provide essential insights into biological functions regarding health and disease. Current measurements of the biomechanical properties of cells require physical contact with cells or pre-loading on the cells. Here, we have developed photoacoustic micro-viscoelastography (PAMVE), which utilizes the phase characteristics of photoacoustic (PA) response, for mapping mechanocellular properties in a load-free manner. PAMVE realizes the local viscoelasticity measurement on the macrophages and red blood cells with micrometer scale. Furthermore, PAMVE can successfully identify the adipose cell and skeletal muscle cell due to the difference in their composition-related biomechanical properties. PAMVE represents an irreplaceable option for interrogating characteristic mechanocellular properties, opening the possibility of studying cellular mechanobiology and pathophysiology.

cellular mechanics photoacoustic viscoelasticity imaging

SCI ; EI

英语

第一

This study was supported by the National Natural Science Foundation of China (61705068, 62275116), Guangdong Science and Technology Department (2022A1515011984), the Natural Science Foundation of Fujian Province (2021J01813), Fujian Medical University Rese["61705068","62275116"] ; National Natural Science Foundation of China[2022A1515011984] ; Guangdong Science and Technology Department[2021J01813] ; Natural Science Foundation of Fujian Province[XRCZX2021004] ; Fujian Medical University Research Foundation of Talented Scholars[2022M721483]

Biochemistry & Molecular Biology ; Biophysics ; Optics

Biochemical Research Methods ; Biophysics ; Optics

WOS:001082115100001

WILEY-V C H VERLAG GMBH

Web of Science

1.Southern Univ Sci & Technol, Dept Biomed Engn, Guangdong Prov Key Lab Adv Biomat, Shenzhen, Guangdong, Peoples R China
2.South China Normal Univ, Coll Biophoton, MOE Key Lab Laser Life Sci, Guangzhou, Peoples R China
3.South China Normal Univ, Inst Laser Life Sci, Coll Biophoton, Guangzhou, Peoples R China
4.Fujian Med Univ, Sch Med Technol & Engn, Fuzhou 350004, Peoples R China

Yang, Fen,Chen, Wei,Chen, Zhongjiang. Photoacoustic micro-viscoelastography for mapping mechanocellular properties[J]. JOURNAL OF BIOPHOTONICS,2023.

Yang, Fen,Chen, Wei,&Chen, Zhongjiang.(2023).Photoacoustic micro-viscoelastography for mapping mechanocellular properties.JOURNAL OF BIOPHOTONICS.

Yang, Fen,et al."Photoacoustic micro-viscoelastography for mapping mechanocellular properties".JOURNAL OF BIOPHOTONICS (2023).