Targeting estrogen receptor signaling for treating heart failure

Qian, Chenyue1; Liu, Jingjin1,2,3,4,5; Liu, Huadong1,2,3,4,5

2023-10-01

10.1007/s10741-023-10356-9

HEART FAILURE REVIEWS   影响因子和分区

1382-4147

1573-7322

Heart failure (HF) is a significant public health problem worldwide. It has long been noted that premenopausal women, compared to postmenopausal women and men, have lower rates for developing this disease, as well as subsequent morbidity and mortality. This difference has been attributed to estrogen playing a cardioprotective role in these women, though exactly how it does so remains unclear. In this review, we examine the presence of estrogen receptors within the cardiovascular system, as well as the role they play behind the cardioprotective effect attributed to estrogen. Furthermore, we highlight the underlying mechanisms behind their alleviation of HF, as well as possible treatment approaches, such as hormone replacement therapy and exercise regimens, to manipulate these mechanisms in treating and preventing HF.

Heart failure Estrogen Estrogen receptor Hormone replacement therapy Cardiac rehabilitation

SCI

英语

通讯

Natural Science Foundation of Shenzhen Science and Technology Innovation Commission[JCYJ20190806153207263] ; National Natural Science Foundation[82200315] ; Guangdong Basic and Applied Basic Research Foundation[2021A1515111145] ; Sanming Project of Medicine in Shenzhen[SZSM201412012] ; Major scientific research project of Shenzhen People's Hospital[SYWGSJCYJ202301]

Cardiovascular System & Cardiology

Cardiac & Cardiovascular Systems

WOS:001079602300001

SPRINGER

CLINICAL MEDICINE

Web of Science

1.Jinan Univ, Clin Med Coll 2, Shenzhen 518020, Guangdong, Peoples R China
2.Southern Univ Sci & Technol, Jinan Univ, Shenzhen Peoples Hosp, Affiliated Hosp 1,Clin Med Coll 2,Dept Cardiol, Shenzhen 518020, Guangdong, Peoples R China
3.Southern Univ Sci & Technol, Jinan Univ, Shenzhen Peoples Hosp,Shenzhen Cardiovasc Minimall, Dept Cardiol,Affiliated Hosp 1,Clin Med Coll 2, Shenzhen, Peoples R China
4.Southern Univ Sci & Technol, Jinan Univ, Shenzhen Peoples Hosp,Affiliated Hosp 1, Shenzhen Key Lab Stem Cell Res & Clin Transformat,, Shenzhen 518020, Guangdong, Peoples R China
5.Southern Univ Sci & Technol, Jinan Univ, Affiliated Hosp 1, Shenzhen Peoples Hosp,Dept Geriatr,Clin Med Coll 2, Shenzhen 518020, Guangdong, Peoples R China

Qian, Chenyue,Liu, Jingjin,Liu, Huadong. Targeting estrogen receptor signaling for treating heart failure[J]. HEART FAILURE REVIEWS,2023.

Qian, Chenyue,Liu, Jingjin,&Liu, Huadong.(2023).Targeting estrogen receptor signaling for treating heart failure.HEART FAILURE REVIEWS.

Qian, Chenyue,et al."Targeting estrogen receptor signaling for treating heart failure".HEART FAILURE REVIEWS (2023).