AgingReG: a curated database of aging regulatory relationships in humans

Piao, Minghui1,2; Feng, Ke3; Liu, Xinyu4; Bai, Xuefeng4,5,6; Zheng, Yuqi1; Sun, Meiling1; Zhao, Peng1; Wang, Yani1; Ban, Xiaofang1; Xiong, Jie1; Shi, Chengyu1; Meng, Li1; Liu, Yuxin1; Yu, Li1; Li, Jing1; Zhong, Shan1; Jiang, Xinjian1; Chen, Yu1; Sun, Xin7,8; Zheng, Yan5,6; Tian, Jinwei1,2,9

2023-10-06

10.1093/database/baad064

DATABASE-THE JOURNAL OF BIOLOGICAL DATABASES AND CURATION   影响因子和分区

1758-0463

Aging and cellular senescence are characterized by a progressive loss of physiological integrity, which could be triggered by aging factors such as physiological, pathological and external factors. Numerous studies have shown that gene regulatory events play crucial roles in aging, increasing the need for a comprehensive repository of regulatory relationships during aging. Here, we established a manually curated database of aging factors (AgingReG, https://bio.liclab.net/Aging-ReG/), focusing on the regulatory relationships during aging with experimental evidence in humans. By curating thousands of published literature, 2157 aging factor entries (1345 aging gene entries, 804 external factor entries and eight aging-related pathway entries) and related regulatory information were manually curated. The regulatory relationships were classified into four types according to their functions: (i) upregulation, which indicates that aging factors upregulate the expression of target genes during aging; (ii) downregulation, which indicates that aging factors downregulate the expression of target genes during aging; (iii) activation, which indicates that aging factors influence the activity of target genes during aging and (iv) inhibition, which indicates that aging factors inhibit the activation of target molecule activity, leading to declined or lost target activity. AgingReG involves 651 upregulating pairs, 632 downregulating pairs, 330 activation-regulating pairs and 34 inhibition-regulating pairs, covering 195 disease types and more than 800 kinds of cells and tissues from 1784 published literature studies. AgingReG provides a user-friendly interface to query, browse and visualize detailed information about the regulatory relationships during aging. We believe that AgingReG will serve as a valuable resource database in the field of aging research.Database URL: https://bio.liclab.net/Aging-ReG/

SCI

英语

其他

National Natural Science Foundation of China["82370343","U21A20391","81971715","82070527"] ; National Key R&D Program of China[2020YFC2005000] ; Shenzhen Natural Science Fund Committee[JCYJ20190807145015194] ; Fok Ying-Tong Education Foundation for Young Teachers[171032] ; Natural Science Foundation of Heilongjiang Province of China[ZD2023H005] ; Key Laboratory of Emergency and Trauma of Ministry of Education (Hainan Medical University)[KLET-202117] ; HMU Marshal Initiative Funding[HMUMIF-21020]

Mathematical & Computational Biology

Mathematical & Computational Biology

WOS:001080233600001

OXFORD UNIV PRESS

Web of Science

1.Harbin Med Univ, Dept Cardiol, Affiliated Hosp 2, 246 Xuefu Rd, Harbin 150086, Peoples R China
2.Harbin Med Univ, Key Lab Myocardial Ischemia, Minist Educ, 246 Xuefu Rd, Harbin 150086, Peoples R China
3.Harbin Med Univ, Coll Bioinformat Sci & Technol, 157 Baojian Rd, Harbin 150086, Peoples R China
4.Harbin Med Univ, Sch Med Informat, Daqing Campus,39 Xinyang Rd, Daqing 163319, Peoples R China
5.Fudan Univ, Human Phenome Inst, State Key Lab Genet Engn, 2005 Songhu Rd, Shanghai 200438, Peoples R China
6.Fudan Univ, Sch Life Sci, 2005 Songhu Rd, Shanghai 200438, Peoples R China
7.Jinan Univ, Clin Med Coll 2, Dept Cardiol, Shenzhen Peoples Hosp, 1017 Dongmen North Rd, Shenzhen 518000, Peoples R China
8.Southern Univ Sci & Technol, Affiliated Hosp 1, 1017 Dongmen North Rd, Shenzhen 518000, Peoples R China
9.Hainan Med Univ, Key Lab Emergency & Trauma, Minist Educ, 3 Xueyuan Rd, Haikou 571199, Peoples R China

Piao, Minghui,Feng, Ke,Liu, Xinyu,et al. AgingReG: a curated database of aging regulatory relationships in humans[J]. DATABASE-THE JOURNAL OF BIOLOGICAL DATABASES AND CURATION,2023,2023.

Piao, Minghui.,Feng, Ke.,Liu, Xinyu.,Bai, Xuefeng.,Zheng, Yuqi.,...&Tian, Jinwei.(2023).AgingReG: a curated database of aging regulatory relationships in humans.DATABASE-THE JOURNAL OF BIOLOGICAL DATABASES AND CURATION,2023.

Piao, Minghui,et al."AgingReG: a curated database of aging regulatory relationships in humans".DATABASE-THE JOURNAL OF BIOLOGICAL DATABASES AND CURATION 2023(2023).