南方科技大学知识苑(SUSTech KC): Protectin D1 Alleviates Myocardial Ischemia/Reperfusion Injury by Regulating PI3K/AKT Signaling Pathway

题名	Protectin D1 Alleviates Myocardial Ischemia/Reperfusion Injury by Regulating PI3K/AKT Signaling Pathway
作者	Zhang, Peng 1 ; Wang, Jin 2 ; Wang, Xingsong 3; Wang, Li 2 ; Xu, Shihai 2; Gong, Ping 2
通讯作者	Xu, Shihai; Gong, Ping
发表日期	2023-08-01
DOI	10.1007/s12265-023-10426-1
发表期刊	JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH 影响因子和分区
ISSN	1937-5387
EISSN	1937-5395
摘要	Myocardial ischemia/reperfusion (I/R) injury after the onset of acute myocardial infarction (AMI) can be life-threatening, and there is no effective strategy for therapeutic intervention. Here, we studied the potential of protectin D1 in protecting from I/R-induced cardiac damages and investigated the underlying mechanisms. An in vivo rat model of I/R after AMI induction was established through the ligation of the left anterior descending (LAD) artery to assess the cardiac functions and evaluate the protective effect of protectin D1. Protectin D1 protected against I/R-induced oxidative stress and inflammation in the rat model, improved the cardiac function, and reduced the infarct size in myocardial tissues. The beneficial effect of protectin D1 was associated with the up-regulation of miRNA-210 and the effects on PI3K/AKT signaling and HIF-1a expression. Together, our data suggest that protectin D1 could serve as a potential cardioprotective agent against I/R-associated cardiac defects.
关键词	Acute myocardial infarction (AMI) Ischemia/reperfusion (I/R) Protectin D1 PI3K/AKT HIF-1a
相关链接	[来源记录]
收录类别	SCI
语种	英语
学校署名	第一 ; 通讯
资助项目	Science and Technology Innovation Foundation of Shenzhen[JCYJ20190806150005453]
WOS研究方向	Cardiovascular System & Cardiology ; Research & Experimental Medicine
WOS类目	Cardiac & Cardiovascular Systems ; Medicine, Research & Experimental
WOS记录号	WOS:001050294600001
出版者	SPRINGER
来源库	Web of Science
引用统计
成果类型	期刊论文
条目标识符	http://sustech.caswiz.com/handle/2SGJ60CL/583031
专题	南方科技大学第一附属医院
作者单位	1.Southern Univ Sci & Technol, Jinan Univ, Shenzhen Peoples Hosp, Dept Cardiol,Affiliated Hosp 1,Clin Med Coll 2, Shenzhen 518020, Guangdong, Peoples R China 2.Southern Univ Sci & Technol, Jinan Univ, Shenzhen Peoples Hosp, Emergency Dept,Affiliated Hosp 1,Clin Med Coll 2, 1017 Dongmen North Rd, Shenzhen 518020, Guangdong, Peoples R China 3.Shouxian Chinese Med Hosp, Dept Anesthesiol, Huainan 232299, Anhui, Peoples R China
第一作者单位	南方科技大学第一附属医院
通讯作者单位	南方科技大学第一附属医院
第一作者的第一单位	南方科技大学第一附属医院
推荐引用方式 GB/T 7714	Zhang, Peng,Wang, Jin,Wang, Xingsong,et al. Protectin D1 Alleviates Myocardial Ischemia/Reperfusion Injury by Regulating PI3K/AKT Signaling Pathway[J]. JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH,2023.
APA	Zhang, Peng,Wang, Jin,Wang, Xingsong,Wang, Li,Xu, Shihai,&Gong, Ping.(2023).Protectin D1 Alleviates Myocardial Ischemia/Reperfusion Injury by Regulating PI3K/AKT Signaling Pathway.JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH.
MLA	Zhang, Peng,et al."Protectin D1 Alleviates Myocardial Ischemia/Reperfusion Injury by Regulating PI3K/AKT Signaling Pathway".JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH (2023).