Experience in the diagnosis and treatment of pneumonia caused by infection with Tropheryma whipplei: A case series

Fang, Zhixiong1; Liu, Qiong2; Tang, Wei1; Yu, Hongyin3; Zou, Min4; Zhang, Haiming1; Xue, Haiyan1; Lin, Sha1; Pei, Yi5; Ai, Jingwen6; Chen, Jun7

2023-06-01

10.1016/j.heliyon.2023.e17132

HELIYON   影响因子和分区

2405-8440

Tropheryma whipplei (TW) is the root cause of Whipple's disease (WD), a rare infectious illness leading to multi-organ impairment. A prominent feature of WD is acute pneumonia, which can be exceedingly challenging to diagnose clinically due to the pathogen's surreptitious nature. However and significantly, with the advent of metagenomic next-generation sequencing (mNGS) of bronchoalveolar lavage fluid (BALF), it offers clinicians a potent tool at their disposal to detect TW infections. The present study conducted a retrospective analysis of clinical data gleaned from five patients in Hunan Province in China. Findings in this study demonstrated the potential of BALF-mNGS in diagnosing pneumonia caused by TW infection.

Tropheryma whipplei Metagenomic next-generation sequencing Bronchoalveolar lavage fluid Pneumonia

SCI

英语

其他

Hunan Province Science and Technology Major project[20200855]

Science & Technology - Other Topics

Multidisciplinary Sciences

WOS:001043458400001

CELL PRESS

Web of Science

1.Cent Hosp Xiangtan, Dept Infect Dis & Publ Hlth, Xiangtan, Hunan, Peoples R China
2.Linxiang Peoples Hosp, Yueyang, Hunan, Peoples R China
3.First Peoples Hosp Huaihua, Ctr Infect Dis, Huaihua, Hunan, Peoples R China
4.Nanhua Univ, Peoples Hosp Xiangtan City 1, Dept Resp & Crit Care Med, Hengyang, Hunan, Peoples R China
5.Changsha Cent Hosp, Dept TB, Changsha, Peoples R China
6.Fudan Univ, Huashan Hosp, Dept Infect Dis, Shanghai, Peoples R China
7.Southern Univ Sci & Technol, Hosp Shenzhen 3, Affiliated Hosp 2, Dept Liver Dis, Shenzhen, Guangdong, Peoples R China

Fang, Zhixiong,Liu, Qiong,Tang, Wei,et al. Experience in the diagnosis and treatment of pneumonia caused by infection with Tropheryma whipplei: A case series[J]. HELIYON,2023,9(6).

Fang, Zhixiong.,Liu, Qiong.,Tang, Wei.,Yu, Hongyin.,Zou, Min.,...&Chen, Jun.(2023).Experience in the diagnosis and treatment of pneumonia caused by infection with Tropheryma whipplei: A case series.HELIYON,9(6).

Fang, Zhixiong,et al."Experience in the diagnosis and treatment of pneumonia caused by infection with Tropheryma whipplei: A case series".HELIYON 9.6(2023).