南方科技大学知识苑(SUSTech KC): IFITM3 restricts RABV infection through inhibiting viral entry and mTORC1-dependent autophagy

题名	IFITM3 restricts RABV infection through inhibiting viral entry and mTORC1-dependent autophagy
作者	Ma, Jiaqi 1,2; Tu, Zhongzhong 1; Du, Shouwen 4; Zhang, Xinying 1; Wang, Jie 1,3; Guo, Jianxiong 1; Feng, Ye 1; He, Hongbin 2; Wang, Hongmei 2; Li, Chang 1; Tu, Changchun 1; Liu, Yan 1
通讯作者	Li, Chang; Tu, Changchun; Liu, Yan
发表日期	2023-09-01
DOI	10.1016/j.vetmic.2023.109823
发表期刊	VETERINARY MICROBIOLOGY 影响因子和分区
ISSN	0378-1135
EISSN	1873-2542
卷号	284
摘要	Rabies, which caused by rabies virus (RABV), is a zoonotic and life-threatening disease with 100% mortality, and there is no effective treatment thus far due to the unclear pathogenesis and less of treatment targets. Interferon-induced transmembrane protein 3 (IFITM3) has recently been identified as an important anti-viral host effector induced by type I interferon. However, the role of IFITM3 in RABV infection has not been elucidated. In this study, we demonstrated that IFITM3 is a crucial restriction factor for RABV, the viral-induced IFITM3 significantly inhibited RABV replication, while knockdown of IFITM3 had the opposite effect. We then identified that IFN beta induces the upregulation of IFITM3 in the absence or presence of RABV infection, meanwhile, IFITM3 positively regulates RABV-triggered production of IFN beta in a feedback manner. In-depth research we found that IFITM3 not only inhibits the virus absorb and entry, but also inhibits viral replication through mTORC1dependent autophagy. All these findings broaden our understanding of IFITM3 function and uncover a novel mechanism against RABV infection.
关键词	IFITM3 RABV IFN beta Autophagy Anti-viral effect
相关链接	[来源记录]
收录类别	SCI
语种	英语
学校署名	其他
资助项目	National Nat-ural Science Foundation of China["31972720","32273093","31902307","31972719"] ; National Key Research and Development Program of China[2022YFD1800100] ; Guangdong Provincial Science and Technology Plan Project[2021B121030015]
WOS研究方向	Microbiology ; Veterinary Sciences
WOS类目	Microbiology ; Veterinary Sciences
WOS记录号	WOS:001031849300001
出版者	ELSEVIER
ESI学科分类	PLANT & ANIMAL SCIENCE
来源库	Web of Science
引用统计	被引频次[WOS]：1
成果类型	期刊论文
条目标识符	http://sustech.caswiz.com/handle/2SGJ60CL/583051
专题	南方科技大学第一附属医院
作者单位	1.Chinese Acad Agr Sci, Changchun Vet Res Inst, Changchun 130122, Peoples R China 2.Shandong Normal Univ, Coll Life Sci, Ruminant Dis Res Ctr, Jinan 250014, Peoples R China 3.Northeast Normal Univ, Engn Res Ctr Glycoconjugates, Sch Life Sci, Minist Educ,Jinlin Prov Key Lab Chem & Biol Changb, Changchun 130024, Peoples R China 4.Southern Univ Sci & Technol, Jinan Univ, Shenzhen Peoples Hosp, Affiliated Hosp 1,Clin Med Coll 2,Dept Infect Dis, Shenzhen 518020, Guangdong, Peoples R China
推荐引用方式 GB/T 7714	Ma, Jiaqi,Tu, Zhongzhong,Du, Shouwen,et al. IFITM3 restricts RABV infection through inhibiting viral entry and mTORC1-dependent autophagy[J]. VETERINARY MICROBIOLOGY,2023,284.
APA	Ma, Jiaqi.,Tu, Zhongzhong.,Du, Shouwen.,Zhang, Xinying.,Wang, Jie.,...&Liu, Yan.(2023).IFITM3 restricts RABV infection through inhibiting viral entry and mTORC1-dependent autophagy.VETERINARY MICROBIOLOGY,284.
MLA	Ma, Jiaqi,et al."IFITM3 restricts RABV infection through inhibiting viral entry and mTORC1-dependent autophagy".VETERINARY MICROBIOLOGY 284(2023).