| 题名 | Advanced Strategies for Overcoming Endosomal/Lysosomal Barrier in Nanodrug Delivery |
| 作者 | |
| 通讯作者 | Qiu, Chong; Guo, Qiuyan; Wang, Jigang |
| 发表日期 | 2023-05-24
|
| DOI | |
| 发表期刊 | |
| ISSN | 2096-5168
|
| EISSN | 2639-5274
|
| 卷号 | 6 |
| 摘要 | Nanocarriers have therapeutic potential to facilitate drug delivery, including biological agents, smallmolecule drugs, and nucleic acids. However, their efficiency is limited by several factors; among which, endosomal/lysosomal degradation after endocytosis is the most important. This review summarizes advanced strategies for overcoming endosomal/lysosomal barriers to efficient nanodrug delivery based on the perspective of cellular uptake and intracellular transport mechanisms. These strategies include promoting endosomal/lysosomal escape, using non-endocytic methods of delivery to directly cross the cell membrane to evade endosomes/lysosomes and making a detour pathway to evade endosomes/ lysosomes. On the basis of the findings of this review, we proposed several promising strategies for overcoming endosomal/lysosomal barriers through the smarter and more efficient design of nanodrug delivery systems for future clinical applications. |
| 相关链接 | [来源记录] |
| 收录类别 | |
| 语种 | 英语
|
| 学校署名 | 通讯
|
| 资助项目 | Fundamental Research Funds for the National Natural Science Foundation["82204322","82104480"]
; Central Public Welfare Research Institutes["ZZ16-ND-10-05","ZZ16-ND-10-13","ZZ16-ND-10-17","ZZ16-ND-10-19","ZZ14-YQ-050","ZZ14-YQ-055","ZZ14-YQ-059","ZZ14-YQ-060","ZZ16-YQ-046"]
; Young Elite Scientists Sponsorship Program by CACM[2021QNRC2B29]
|
| WOS研究方向 | Science & Technology - Other Topics
|
| WOS类目 | Multidisciplinary Sciences
|
| WOS记录号 | WOS:001001555900001
|
| 出版者 | |
| 来源库 | Web of Science
|
| 引用统计 |
被引频次[WOS]：74
|
| 成果类型 | 期刊论文 |
| 条目标识符 | http://sustech.caswiz.com/handle/2SGJ60CL/583086 |
| 专题 | 南方科技大学第一附属医院 |
| 作者单位 | 1.China Acad Chinese Med Sci, Artemisinin Res Ctr, Beijing 100700, Peoples R China 2.China Acad Chinese Med Sci, Inst Chinese Mat Med, Beijing 100700, Peoples R China 3.Southern Univ Sci & Technol, Shenzhen Peoples Hosp, Affiliated Hosp 1, Dept Nephrol, Shenzhen 518020, Guangdong, Peoples R China 4.Southern Univ Sci & Technol, Shenzhen Peoples Hosp, Affiliated Hosp 1, Shenzhen Clin Res Ctr Geriatr, Shenzhen 518020, Guangdong, Peoples R China |
| 通讯作者单位 | 南方科技大学第一附属医院 |
| 推荐引用方式 GB/T 7714 |
Qiu, Chong,Xia, Fei,Zhang, Junzhe,et al. Advanced Strategies for Overcoming Endosomal/Lysosomal Barrier in Nanodrug Delivery[J]. RESEARCH,2023,6.
|
| APA |
Qiu, Chong.,Xia, Fei.,Zhang, Junzhe.,Shi, Qiaoli.,Meng, Yuqing.,...&Wang, Jigang.(2023).Advanced Strategies for Overcoming Endosomal/Lysosomal Barrier in Nanodrug Delivery.RESEARCH,6.
|
| MLA |
Qiu, Chong,et al."Advanced Strategies for Overcoming Endosomal/Lysosomal Barrier in Nanodrug Delivery".RESEARCH 6(2023).
|
| 条目包含的文件 | 条目无相关文件。 | |||||
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。
;
修改评论