南方科技大学知识苑(SUSTech KC): Stereodivergent Synthesis of Enantioenriched 2-Pyrrolidones via Diastereoselective Hydrogenation of ?,?-Unsaturated ?-Lactams

题名	Stereodivergent Synthesis of Enantioenriched 2-Pyrrolidones via Diastereoselective Hydrogenation of ?,?-Unsaturated ?-Lactams
作者	Guo, Siyuan1,2 ; Ma, Baode1,2 ; Chen, Gen-Qiang3,4 ; Zhang, Xumu1,2
通讯作者	Ma, Baode; Chen, Gen-Qiang; Zhang, Xumu
发表日期	2023-03-01
DOI	10.1021/acs.orglett.3c005322426Org
发表期刊	ORGANIC LETTERS 影响因子和分区
ISSN	1523-7060
EISSN	1523-7052
摘要	Synthesis of optically enriched racetam analogues was achieved via highly remote diastereocontrolled and enantiocontrolled Pd/C-catalyzed hydrogenation of alpha,beta-unsaturated gamma-lactams. Various mono-and disubstituted 2-pyrrolidones were obtained in excellent yields and stereoselectivities, and a concise and large-scale synthesis of brivaracetam was developed from inexpensive L-2-aminobutyric acid. Surprisingly, stereodivergent hydrogenation was observed by modifying remote functionalized stereocenters and additives, which would provide alternative stereochemical options of chiral racetams synthesis.
相关链接	[来源记录]
收录类别	SCI
语种	英语
学校署名	第一 ; 通讯
资助项目	National Key R&D Program of China[2021YFA1500201] ; Shenzhen Nobel Prize Scientists Laboratory Project[C17213101] ; Stable Support Plan Program of Shenzhen Natural Science Fund[20200925161222002] ; Key-Area Research and Development Program of Guangdong Province[2020B010188001] ; Innovative Team of Universities in Guangdong Province[2020KCXTD016] ; National Natural Science Foundation of China["21991113","22171129"] ; Shenzhen Science and Technology Innovation Committee[21901107] ; null[JCYJ20210324104202007]
WOS研究方向	Chemistry
WOS类目	Chemistry, Organic
WOS记录号	WOS:000980090700001
出版者	AMER CHEMICAL SOC
ESI学科分类	CHEMISTRY
来源库	Web of Science
引用统计
成果类型	期刊论文
条目标识符	http://sustech.caswiz.com/handle/2SGJ60CL/583124
专题	理学院_化学系前沿与交叉科学研究院
作者单位	1.Southern Univ Sci & Technol, Med X Pingshan, Shenzhen 518000, Peoples R China 2.Southern Univ Sci & Technol, Dept Chem, Shenzhen 518000, Peoples R China 3.Southern Univ Sci & Technol, Acad Adv Interdisciplinary Studies, Shenzhen 518055, Peoples R China 4.Southern Univ Sci & Technol, Guangdong Prov Key Lab Catalysis, Shenzhen 518055, Peoples R China
第一作者单位	南方科技大学; 化学系
通讯作者单位	南方科技大学; 化学系; 前沿与交叉科学研究院
第一作者的第一单位	南方科技大学
推荐引用方式 GB/T 7714	Guo, Siyuan,Ma, Baode,Chen, Gen-Qiang,et al. Stereodivergent Synthesis of Enantioenriched 2-Pyrrolidones via Diastereoselective Hydrogenation of ?,?-Unsaturated ?-Lactams[J]. ORGANIC LETTERS,2023.
APA	Guo, Siyuan,Ma, Baode,Chen, Gen-Qiang,&Zhang, Xumu.(2023).Stereodivergent Synthesis of Enantioenriched 2-Pyrrolidones via Diastereoselective Hydrogenation of ?,?-Unsaturated ?-Lactams.ORGANIC LETTERS.
MLA	Guo, Siyuan,et al."Stereodivergent Synthesis of Enantioenriched 2-Pyrrolidones via Diastereoselective Hydrogenation of ?,?-Unsaturated ?-Lactams".ORGANIC LETTERS (2023).