南方科技大学知识苑(SUSTech KC): Improved prognostic prediction model for liver cancer based on biomarker data screened by combined methods

题名	Improved prognostic prediction model for liver cancer based on biomarker data screened by combined methods
作者	Su, Zhiyue 1; Li, Chengquan 2; Fu, Haitian 2; Wang, Liyang 2; Wu, Meilong 3,4; Feng, Xiaobin 2
通讯作者	Feng, Xiaobin
发表日期	2023
DOI	10.3934/mbe.2023246
发表期刊	MATHEMATICAL BIOSCIENCES AND ENGINEERING 影响因子和分区
ISSN	1547-1063
EISSN	1551-0018
卷号	20 期号:3
摘要	Liver cancer is a common cause of death from cancer in the population, with the 4th highest mortality rate from cancer worldwide. The high recurrence rate of hepatocellular carcinoma after surgery is an important cause of high mortality among patients. In this paper, based on eight scheduled core markers of liver cancer, an improved feature screening algorithm was proposed based on the analysis of the basic principles of the random forest algorithm, and the system was finally applied to liver cancer prognosis prediction to improve the prediction of biomarkers for liver cancer recurrence, and the impact of different algorithmic strategies on the prediction accuracy was compared and analyzed. The results showed that the improved feature screening algorithm was able to reduce the feature set by about 50% while ensuring that the prediction accuracy was reduced within 2%.
关键词	gene sequencing data liver cancer recurrence predictive model biomarkers random forest
相关链接	[来源记录]
收录类别	SCI
语种	英语
学校署名	其他
WOS研究方向	Mathematical & Computational Biology
WOS类目	Mathematical & Computational Biology
WOS记录号	WOS:000961088000005
出版者	AMER INST MATHEMATICAL SCIENCES-AIMS
来源库	Web of Science
引用统计	被引频次[WOS]：1
成果类型	期刊论文
条目标识符	http://sustech.caswiz.com/handle/2SGJ60CL/583134
专题	南方科技大学第一附属医院
作者单位	1.UCL, Fac Math & Phys Sci, London WC1E 6BT, England 2.Tsinghua Univ, Sch Clin Med, Beijing 100084, Peoples R China 3.Jinan Univ, Shenzhen Peoples Hosp, Clin Med Coll 2, Dept Gen Surg,Div Hepatobiliary & Pancreas Surg, Shenzhen 518020, Guangdong, Peoples R China 4.Southern Univ Sci & Technol, Affiliated Hosp 1, Shenzhen 518020, Guangdong, Peoples R China
推荐引用方式 GB/T 7714	Su, Zhiyue,Li, Chengquan,Fu, Haitian,et al. Improved prognostic prediction model for liver cancer based on biomarker data screened by combined methods[J]. MATHEMATICAL BIOSCIENCES AND ENGINEERING,2023,20(3).
APA	Su, Zhiyue,Li, Chengquan,Fu, Haitian,Wang, Liyang,Wu, Meilong,&Feng, Xiaobin.(2023).Improved prognostic prediction model for liver cancer based on biomarker data screened by combined methods.MATHEMATICAL BIOSCIENCES AND ENGINEERING,20(3).
MLA	Su, Zhiyue,et al."Improved prognostic prediction model for liver cancer based on biomarker data screened by combined methods".MATHEMATICAL BIOSCIENCES AND ENGINEERING 20.3(2023).