南方科技大学知识苑(SUSTech KC): Suppressing host pyroptosis by a ubiquitin-activated phospholipid phosphatase of <i>Mycobacterium tuberculosis</i>

题名	Suppressing host pyroptosis by a ubiquitin-activated phospholipid phosphatase of Mycobacterium tuberculosis
作者	Feng, Qishun1 ; Zhang, Guoliang 1; Lu, Hongzhou 1,2
通讯作者	Lu, Hongzhou
发表日期	2023-03-01
DOI	10.5582/ddt.2022.01104
发表期刊	DRUG DISCOVERIES AND THERAPEUTICS 影响因子和分区
ISSN	1881-7831
EISSN	1881-784X
摘要	Tuberculosis (TB) is a major public health problem that causes millions of deaths in humans around the world, and the bacterial pathogen Mycobacterium tuberculosis (Mtb) is responsible for this disease. Evidence suggested that the inflammasome-pyroptosis pathway is crucial for preventing Mtb infection. Uncertainty exists regarding whether and how these infections can bypass this immune system by Mtb. A recent Science article by Chai et al. (doi: 10.1126/science.abq0132) revealed a novel role by a eukaryotic-like effector called PtpB during Mtb infection. The PtpB functions as a phospholipid phosphatase suppressing gasdermin D (GSDMD) dependent pyroptosis. And notably, the phospholipid phosphatase activity of PtpB is dependent on binding with mono-ubiquitin (Ub) of the host.
关键词	Mycobacterium tuberculosis phospholipid phosphatase ubiquitination pyroptosis
相关链接	[来源记录]
收录类别	ESCI
语种	英语
学校署名	第一 ; 通讯
资助项目	Shenzhen Scientific and Technological Foundation[KCXFZ20211020163 545004] ; Guangdong Scientific and Technological Foundation["556 2019B1515120041","2020B1111170014"]
WOS研究方向	Pharmacology & Pharmacy
WOS类目	Pharmacology & Pharmacy
WOS记录号	WOS:000963602700001
出版者	INT RESEARCH & COOPERATION ASSOC BIO & SOCIO-SCIENCES ADVANCEMENT
来源库	Web of Science
引用统计
成果类型	期刊论文
条目标识符	http://sustech.caswiz.com/handle/2SGJ60CL/583135
专题	南方科技大学第二附属医院南方科技大学第一附属医院
作者单位	1.Southern Univ Sci & Technol, Shenzhen Peoples Hosp 3, Natl Clin Res Ctr Infect Dis, Guangdong Prov Clin Res Ctr TB, Shenzhen, Peoples R China 2.Southern Univ Sci & Technol, Affiliated Hosp 2, Natl Clin Res Ctr Infect Dis, 29 Bulan Rd, Shenzhen 518112, Guangdong, Peoples R China
第一作者单位	南方科技大学第二附属医院; 南方科技大学第一附属医院
通讯作者单位	南方科技大学第二附属医院; 南方科技大学第一附属医院
第一作者的第一单位	南方科技大学第二附属医院; 南方科技大学第一附属医院
推荐引用方式 GB/T 7714	Feng, Qishun,Zhang, Guoliang,Lu, Hongzhou. Suppressing host pyroptosis by a ubiquitin-activated phospholipid phosphatase of Mycobacterium tuberculosis[J]. DRUG DISCOVERIES AND THERAPEUTICS,2023.
APA	Feng, Qishun,Zhang, Guoliang,&Lu, Hongzhou.(2023).Suppressing host pyroptosis by a ubiquitin-activated phospholipid phosphatase of Mycobacterium tuberculosis.DRUG DISCOVERIES AND THERAPEUTICS.
MLA	Feng, Qishun,et al."Suppressing host pyroptosis by a ubiquitin-activated phospholipid phosphatase of Mycobacterium tuberculosis".DRUG DISCOVERIES AND THERAPEUTICS (2023).