南方科技大学知识苑(SUSTech KC): Functionalized Rhodium Nanoparticles as Antimicrobial Agents for Treatment of Drug-Resistant Skin and Soft Tissue Infections

题名	Functionalized Rhodium Nanoparticles as Antimicrobial Agents for Treatment of Drug-Resistant Skin and Soft Tissue Infections
作者	Tan, Qingqin 1; Chen, Zhenxing 2,3,4; Liu, Lei 1 ; Huang, Xi1,2,3
通讯作者	Liu, Lei; Huang, Xi
发表日期	2023-07-01
DOI	10.1002/adhm.202203200
发表期刊	ADVANCED HEALTHCARE MATERIALS 影响因子和分区
ISSN	2192-2640
EISSN	2192-2659
卷号	12 期号:19
摘要	Skin and soft tissue infections (SSTIs) are among the most common bacterial infections reported in outpatients. Drug-resistant bacteria are the major cause of treatment failure and increased mortality rate in patients with SSTIs, posing significant challenges to human health. In this study, new-generation rhodium nanoplates (RhNPs) and glycol chitosan- and polydopamine-functionalized RhNPs (Rh@GCS) are developed for the treatment of drug-resistant SSTIs. RhNPs exhibited favorable antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA) and Ag-resistant MRSA. The modified Rh@GCS exhibited enhanced antibacterial activity and can directly kill various drug-resistant bacteria by increasing the permeability of cell membranes, including gram-positive MRSA and gram-negative multidrug-resistant Escherichia coli (E.coli) and Pseudomonas aeruginosa (PA). Moreover, Rh@GCS effectively inhibited bacterial growth and promoted the healing of skin lesions in MRSA-induced SSTI mouse models. These results suggest that Rh@GCS is a promising nonantibiotic antimicrobial agent for the treatment of drug-resistant SSTIs.
关键词	antibacterial activity drug-resistant bacteria rhodium nanoparticles skin and soft tissue infections
相关链接	[来源记录]
收录类别	SCI
语种	英语
学校署名	第一 ; 通讯
资助项目	National Natural Science Foundation of China[82072062] ; National Science and Technology Key Projects for Major Infectious Diseases[2017ZX10302301-002] ; Development Project of Foshan Fourth People's Hospital["FSSYKF-2020003","FSSYKF-2020017"] ; Department of Science and Technology of Guangdong Province to the Guangdong Provincial Key Laboratory of Biomedical Imaging[2018B030322006]
WOS研究方向	Engineering ; Science & Technology - Other Topics ; Materials Science
WOS类目	Engineering, Biomedical ; Nanoscience & Nanotechnology ; Materials Science, Biomaterials
WOS记录号	WOS:000963124900001
出版者	WILEY
来源库	Web of Science
引用统计	被引频次[WOS]：1
成果类型	期刊论文
条目标识符	http://sustech.caswiz.com/handle/2SGJ60CL/583136
专题	南方科技大学第二附属医院南方科技大学第一附属医院
作者单位	1.Southern Univ Sci & Technol, Shenzhen Peoples Hosp 3, Natl Clin Res Ctr Infect Dis, Affiliated Hosp 2, Shenzhen 518112, Guangdong, Peoples R China 2.Sun Yat Sen Univ, Affiliated Hosp 5, Ctr Infect & Immun, Zhuhai 519000, Guangdong, Peoples R China 3.Sun Yat Sen Univ, Affiliated Hosp 5, Guangdong Prov Key Lab Biomed Imaging, Zhuhai 519000, Guangdong, Peoples R China 4.Kingcell Regenerat Med Guangdong Co, Zhuhai 519000, Guangdong, Peoples R China
第一作者单位	南方科技大学第二附属医院; 南方科技大学第一附属医院
通讯作者单位	南方科技大学第二附属医院; 南方科技大学第一附属医院
第一作者的第一单位	南方科技大学第二附属医院; 南方科技大学第一附属医院
推荐引用方式 GB/T 7714	Tan, Qingqin,Chen, Zhenxing,Liu, Lei,et al. Functionalized Rhodium Nanoparticles as Antimicrobial Agents for Treatment of Drug-Resistant Skin and Soft Tissue Infections[J]. ADVANCED HEALTHCARE MATERIALS,2023,12(19).
APA	Tan, Qingqin,Chen, Zhenxing,Liu, Lei,&Huang, Xi.(2023).Functionalized Rhodium Nanoparticles as Antimicrobial Agents for Treatment of Drug-Resistant Skin and Soft Tissue Infections.ADVANCED HEALTHCARE MATERIALS,12(19).
MLA	Tan, Qingqin,et al."Functionalized Rhodium Nanoparticles as Antimicrobial Agents for Treatment of Drug-Resistant Skin and Soft Tissue Infections".ADVANCED HEALTHCARE MATERIALS 12.19(2023).