| 题名 | Leishmania Regulated MTDH Expression to Suppress Dendritic Cells |
| 作者 | |
| 通讯作者 | Wei, Lanlan; Chu, Ming |
| 发表日期 | 2023
|
| DOI | |
| 发表期刊 | |
| ISSN | 0040-8727
|
| EISSN | 1349-3329
|
| 卷号 | 259期号:1 |
| 摘要 | This study aimed to investigate the correlation between Leishmania infection and dendritic cell infiltration and explore the underlying molecular mechanism how Leishmania infection regulates dendritic cell infiltration. Three datasets, GSE63931, GSE80008 and GSE77528 were combined and their batch effects were removed by Combat function in sva R package. Immune cell infiltrations were estimated using the Microenvironment Cell Populations-counter (MCP-counter) R package. Statistical results were verified by Student's t test. The differential expression of metadherin (MTDH) was identified by Limma R package. The correlation between MTDH expression and dendritic cell infiltration was estimated by Pearson's product moment correlation coefficient. GDS5086 was used to explore MTDH expression pattern in dendritic cells infected with Leishmania. Compared with normal samples, 5 types of immune cells showed differential infiltration in leishmaniasis samples, including T cells, CD8+ T cells, dendritic cells, cytotoxic lymphocytes and B lineage cells. Among these, only DCs were significantly suppressed in leishmaniasis samples. Notably, MTDH expression was differential between leishmaniasis and normal samples. There was a significant correlation between MTDH expression and dendritic cell infiltration. In conclusion, these results demonstrate that Leishmania infection leads to the downregulation of MTDH expression and the suppression of dendritic cell infiltration. |
| 关键词 | |
| 相关链接 | [来源记录] |
| 收录类别 | |
| 语种 | 英语
|
| 学校署名 | 通讯
|
| 资助项目 | null[LGKCYLWS2020101]
|
| WOS研究方向 | General & Internal Medicine
; Research & Experimental Medicine
|
| WOS类目 | Medicine, General & Internal
; Medicine, Research & Experimental
|
| WOS记录号 | WOS:000904678600007
|
| 出版者 | |
| ESI学科分类 | CLINICAL MEDICINE
|
| 来源库 | Web of Science
|
| 引用统计 | |
| 成果类型 | 期刊论文 |
| 条目标识符 | http://sustech.caswiz.com/handle/2SGJ60CL/583148 |
| 专题 | 南方科技大学第二附属医院 |
| 作者单位 | 1.Third Peoples Hosp Shenzhen, Dept Neurosurg, 29 Bulan Rd, Shenzhen 518112, Guangdong, Peoples R China 2.Harbin Med Univ, Affiliated Hosp 1, Sch Stomatol, Harbin, Heilongjiang, Peoples R China 3.Sun Yat Sen Univ, Affiliated Hosp 7, Clin Lab, Shenzhen, Guangdong, Peoples R China 4.Southern Univ Sci & Technol, Peoples Hosp Shenzhen 3, Natl Clin Res Ctr Infect Dis, Inst Hepatol,Hosp 2, 29 Bulan Rd, Shenzhen 518000, Guangdong, Peoples R China |
| 通讯作者单位 | 南方科技大学第二附属医院 |
| 推荐引用方式 GB/T 7714 |
Tang, Lu,Yu, Siyang,Dong, Baijing,et al. Leishmania Regulated MTDH Expression to Suppress Dendritic Cells[J]. TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE,2023,259(1).
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| APA |
Tang, Lu.,Yu, Siyang.,Dong, Baijing.,Zhang, Shengkun.,Xu, Wanzhen.,...&Chu, Ming.(2023).Leishmania Regulated MTDH Expression to Suppress Dendritic Cells.TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE,259(1).
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| MLA |
Tang, Lu,et al."Leishmania Regulated MTDH Expression to Suppress Dendritic Cells".TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE 259.1(2023).
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| 条目包含的文件 | 条目无相关文件。 | |||||
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