Immune microenvironment and therapeutic progress of recurrent hepatocellular carcinoma after liver transplantation

Jin, Xin1,2; Ma, Xiaoting3; Zhao, Dong1,2; Yang, Lin3; Ma, Nan1,2

2023-02-01

10.1016/j.tranon.2022.101603

TRANSLATIONAL ONCOLOGY   影响因子和分区

1936-5233

HCC is a highly lethal tumor, and orthotopic liver transplantation, as one of the radical treatment methods for HCC, has opened-up a new therapeutic approach for the treatment of primary liver cancer. However, tumor recurrence after liver transplantation is the main reason that affects the long-term survival of recipients. At present, the application of ICIs has brought dawn to patients with refractory HCC. However, because of the special immune tolerance state created by long-term oral immunosuppressants in patients with HCC after liver transplantation, the current focus is how to regulate the immune balance of such patients and simultaneously maximize the anti-tumor effect. This article reviews the relationship between liver cancer and immunity, im-mune tolerance of liver transplantation, immune microenvironment after liver transplantation for HCC, and the application of immunotherapy in the recurrence of liver transplantation for HCC.

ICI HCC Liver transplantation PD-1 Tumor recurrence

SCI

英语

第一 ; 通讯

null[SZXK079]

Oncology

Oncology

WOS:000911260300001

ELSEVIER SCIENCE INC

Web of Science

1.Southern Univ Sci & Technol, Shenzhen Peoples Hosp 3, Div Liver Surg, Natl Clin Res Ctr Infect Dis,Affiliated Hosp 2, 29 Bulan Rd, Shenzhen 518112, Guangdong, Peoples R China
2.Southern Univ Sci & Technol, Shenzhen Peoples Hosp 3, Organ Transplantat Ctr, Natl Clin Res Ctr Infect Dis,Affiliated Hosp 2, 29 Bulan Rd, Shenzhen 518112, Guangdong, Peoples R China
3.Chinese Acad Med Sci & Peking Union Med Coll, Natl Clin Res Ctr Canc, Natl Canc Ctr, Dept Med Oncol,Canc Hosp, 17 Panjiayuan Nanli, Beijing 100021, Peoples R China

Jin, Xin,Ma, Xiaoting,Zhao, Dong,et al. Immune microenvironment and therapeutic progress of recurrent hepatocellular carcinoma after liver transplantation[J]. TRANSLATIONAL ONCOLOGY,2023,28.

Jin, Xin,Ma, Xiaoting,Zhao, Dong,Yang, Lin,&Ma, Nan.(2023).Immune microenvironment and therapeutic progress of recurrent hepatocellular carcinoma after liver transplantation.TRANSLATIONAL ONCOLOGY,28.

Jin, Xin,et al."Immune microenvironment and therapeutic progress of recurrent hepatocellular carcinoma after liver transplantation".TRANSLATIONAL ONCOLOGY 28(2023).