The Geometric Effects on the Stress of Arterial Atherosclerotic Plaques: A Computational Study

Liu，H.1; Leung，T.2; Wong，A.2; Chen，F.3; Zheng，D.1

10.1109/EMBC.2019.8857885

2019-07-01

1557-170X

978-1-5386-1312-2

Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS

6948-6951

23-27 July 2019

Berlin, Germany

345 E 47TH ST, NEW YORK, NY 10017 USA

Institute of Electrical and Electronics Engineers Inc.

Background: The rupture of atherosclerotic plaques could cause serious clinical events. The wall shear stress (WSS) and axial plaque stress (APS) could reflect the risk of plaque rupture. This study aimed to quantitatively investigate the geometric effects on WSS and APS using computational fluid dynamics (CFD).Methods: 63 plaque models were developed from three severities (75%, 82%, and 89% in area), three eccentricities (the deviation of plaque throat from the arterial centerline: 0, 0.375 and 0.75mm), and 7 different length combinations of the proximal and distal stenotic segments (2mm-5mm, 3mm-5mm, 4mm-5mm, 5mm-5mm, 5mm-4mm, 5mm-3mm, 5mm-2mm). For each model, CFD simulation was performed to calculate the maximum and area-averaged WSS and APS on the proximal and distal stenotic segments. The multivariate analysis of variance and linear regression analysis were performed to quantitatively investigate the geometry-stress relationship.The results showed that, the severity and eccentricity of a plaque were linearly related to its WSS and APS. APS value on a segment (proximal or distal) of the plaque depended on the segmental length It was also shown that the difference of APS between proximal and distal segments depended exclusively on the difference of length between segments (all p<0.05).Conclusion: The geometry of a plaque influences its WSS and APS. APS and its proximal/distal difference depend on the segmental lengths.

Stress Atherosclerosis Arteries Geometry Analytical models Analysis of variance Computational fluid dynamics

其他

英语

EI ; CPCI-S

Engineering

Engineering, Biomedical ; Engineering, Electrical & Electronic

WOS:000557295307089

20200308036003

Regression analysis ; Geometry ; Multivariant analysis ; Computational fluid dynamics

Computer Applications:723.5 ; Mathematics:921 ; Statistical Methods:922 ; Mathematical Statistics:922.2 ; Mechanics:931.1

2-s2.0-85077874390

Scopus

1.Medical Technology Research Centre and School of Allied Health,Faculty of Health Education,Medicine and Social Care,Anglia Ruskin University,Chelmsford, Essex,Bishop Road,United Kingdom
2.Department of Medicine and Therapeutics,Chinese University of Hong Kong,Shatin,Hong Kong
3.Department of Electrical and Electronic Engineering,Southern University of Science and Technology,Shenzhen,China

Liu，H.,Leung，T.,Wong，A.,et al. The Geometric Effects on the Stress of Arterial Atherosclerotic Plaques: A Computational Study[C]. 345 E 47TH ST, NEW YORK, NY 10017 USA:Institute of Electrical and Electronics Engineers Inc.,2019:6948-6951.