Association of major depressive disorder and increased risk of irritable bowel syndrome: A population-based cohort study and a two-sample Mendelian randomization study in the UK biobank

Wang，Weiwei1,2,3; Wang，Mengying1,2; Peng，Hexiang1,2; Huang，Jie4; Wu，Tao1,2

2024-01-15

10.1016/j.jad.2023.10.111

Journal of Affective Disorders   影响因子和分区

0165-0327

1573-2517

Objective: To examine the association between depression and the risk of incident irritable bowel syndrome (IBS). Methods: We included 98,564 participants free of IBS in the UK biobank. Depression was defined by self-report and Hospital Episode Statistics. The main outcome was incident IBS. Cox proportional hazards regression models and two-sample mendelian randomization were performed to estimate the risk of incident IBS. Results: Among 98,564 participants, 8770 (8.9 %) participants had a depression diagnosis at baseline. During a median of 12.9-year follow-up, 224 cases of incident IBS were identified in patients with depression (2.0 per 1000 person-years), compared with 1625 cases in reference individuals (1.5 per 1000 person-years). After adjustment, the hazard ratio of incident IBS associated with depression was 1.26 (95 % CI: 1.01–1.41). Sensitivity analysis indicated similar results. The two-sample mendelian randomization based on the inverse variance weighted method provided evidence for the harmful role of depression in an increased risk of IBS with an OR of 1.57 (95 % CI: 1.24–1.99). Limitations: Depression was mainly measured by self-report online CIDI-SF in the current study, rather than the gold diagnostic criteria including clinical structured interview, which might lead to potential measurement error. Lifestyle behaviors might change during the long-term follow-up, and time-varying covariates (i.e., smoking and alcohol status) may bias the estimate. Conclusions: Depression is associated with an increased risk of incident IBS. Further studies are warranted to confirm the role of depression on incident IBS and elucidate the underlying mechanisms.

Cohort study Depression Irritable bowel syndrome Mendelian randomization

SCI ; SSCI

英语

通讯

PSYCHIATRY/PSYCHOLOGY

2-s2.0-85175467690

Scopus

1.Department of Epidemiology and Biostatistics,School of Public Health,Peking University,Beijing,38 Xueyuan Road, Haidian District,100191,China
2.Key Laboratory of Epidemiology of Major Diseases,Peking University,Ministry of Education,Beijing,100191,China
3.Beijing Key Laboratory of Mental Disorders,National Clinical Research Center for Mental Disorders,National Center for Mental Disorders,Beijing Anding Hospital,Capital Medical University,Beijing,5 Ankang Lane, Xicheng District,100088,China
4.School of Public Health and Emergency Management,Southern University of Science and Technology,Shenzhen,518055,China

Wang，Weiwei,Wang，Mengying,Peng，Hexiang,et al. Association of major depressive disorder and increased risk of irritable bowel syndrome: A population-based cohort study and a two-sample Mendelian randomization study in the UK biobank[J]. Journal of Affective Disorders,2024,345:419-426.

Wang，Weiwei,Wang，Mengying,Peng，Hexiang,Huang，Jie,&Wu，Tao.(2024).Association of major depressive disorder and increased risk of irritable bowel syndrome: A population-based cohort study and a two-sample Mendelian randomization study in the UK biobank.Journal of Affective Disorders,345,419-426.

Wang，Weiwei,et al."Association of major depressive disorder and increased risk of irritable bowel syndrome: A population-based cohort study and a two-sample Mendelian randomization study in the UK biobank".Journal of Affective Disorders 345(2024):419-426.