Hepatotoxic response of perfluorooctane sulfonamide (PFOSA) in early life stage zebrafish (Danio rerio) is greater than perfluorooctane sulfonate (PFOS)

Xuan，Rongrong1; Qiu，Xiaojian1; Wang，Jiazhen2; Liu，Shuai3; Magnuson，Jason T.4; Xu，Bentuo5; Qiu，Wenhui1,2; Zheng，Chunmiao2,6

2024-01-05

10.1016/j.jhazmat.2023.132552

Journal of Hazardous Materials   影响因子和分区

0304-3894

1873-3336

Perfluorooctane sulfonamide (PFOSA), a typical perfluorooctane sulfonate precursor (PreFOS), has been detected in the aquatic environment globally. However, the effects of PFOSA at levels measured in the environment have not been well characterized in aquatic organisms. In this study, we evaluated the transcriptional, biochemical, histopathological, and morphological effects of PFOSA to characterize the underlying mechanisms of toxicity by using a universal model in aquatic ecotoxicology, zebrafish (Danio rerio). Transcriptional changes in PFOSA-exposed zebrafish predicted hepatic fibrosis and associated immune function. Subsequent, sublethal impacts were observed, which included significant alterations in liver-specific protein levels, increased immune cell numbers, and liver pathological structural damage. In addition, we compared the effects caused by PFOSA and perfluorooctane sulfonate (PFOS) at the same exposure concentration and found a greater hepatotoxic effect of PFOSA relative to PFOS, indicating that the adverse impacts of PFOSA may be more severe. This was the first study to comparatively explore the hepatotoxic response of PFOSA and PFOS in aquatic organisms, which can be used for ecological risk assessments of PreFOS compounds.

Hepatotoxicity PFOS PFOSA PreFOS Zebrafish

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英语

通讯

ENGINEERING

2-s2.0-85171427543

Scopus

1.The First Affiliated Hospital of Ningbo University,Ningbo,315020,China
2.Guangdong Provincial Key Laboratory of Soil and Groundwater Pollution Control,School of Environmental Science and Engineering,Southern University of Science and Technology,Shenzhen,1088 Xueyuan Avenue, Nanshan District,518055,China
3.Institute of Microbiology,Jiangxi Academy of Sciences,Nanchang,330096,China
4.US Geological Survey,Columbia Environmental Research Center,Columbia,United States
5.National and Local Joint Engineering Research Center of Ecological Treatment Technology for Urban Water Pollution,School of Life and Environmental Science,Wenzhou University,Wenzhou,Chashan University Town,325035,China
6.EIT Institute for Advanced Study,Ningbo,568 Tongxin Road, Zhenhai District,315410,China

Xuan，Rongrong,Qiu，Xiaojian,Wang，Jiazhen,et al. Hepatotoxic response of perfluorooctane sulfonamide (PFOSA) in early life stage zebrafish (Danio rerio) is greater than perfluorooctane sulfonate (PFOS)[J]. Journal of Hazardous Materials,2024,461.

Xuan，Rongrong.,Qiu，Xiaojian.,Wang，Jiazhen.,Liu，Shuai.,Magnuson，Jason T..,...&Zheng，Chunmiao.(2024).Hepatotoxic response of perfluorooctane sulfonamide (PFOSA) in early life stage zebrafish (Danio rerio) is greater than perfluorooctane sulfonate (PFOS).Journal of Hazardous Materials,461.

Xuan，Rongrong,et al."Hepatotoxic response of perfluorooctane sulfonamide (PFOSA) in early life stage zebrafish (Danio rerio) is greater than perfluorooctane sulfonate (PFOS)".Journal of Hazardous Materials 461(2024).