Platelet membrane fusion liposome loaded with type I AIE photosensitizer to induce chemoresistance cancer pyroptosis and immunogenic cell death for enhancing cancer immunotherapy

Chen，Hao1; Luo，Xi1; Huang，Qinghua3; Liu，Zeming5; Lyu，Meng4; Chen，Dexin1; Mo，Jianlan2; Zhu，Daoming1

2023-11-15

10.1016/j.cej.2023.146276

Chemical Engineering Journal   影响因子和分区

1385-8947

1873-3212

Cancer cells often develop resistance to chemotherapy induced apoptosis, and targeting non-apoptosis-related pathways is a potential anti-drug resistant tumor strategy. Here, we designed a platelet membrane fusion liposome nanovesicle system (named TFL) loaded with type I aggregation induced-emission (AIE) photosensitizer (TBP-2), which is used to promote the pyroptosis and immunogenic cell death (ICD) of chemoresistance breast cancer cells. Because of the highly expressed P-selectin protein in platelets, TFL can target the highly expressed CD44 receptor in chemoresistance breast cancer cells and deliver TBP-2 molecules to these cells. Under the irradiation of external light sources, TBP-2 achieves type-I photodynamic therapy (PDT), generating a large number of hydroxyl free radicals, inducing pyroptosis and ICD of chemoresistance cancer cells, promoting DC cell maturation and T cell infiltration. In vivo animal experiments have shown that the TFL system can promote T cell immunity, slow down distal chemoresistance tumor growth, achieve immune memory effect, and inhibit chemoresistance tumor rechallenge. Compared with high-dose chemotherapy, TFL + L has better immune stimulation and therapeutic effect on drug-resistant breast cancer. This system may become an adjuvant therapy for clinical chemotherapy in the future, further enhancing the immune response and therapy effect of drug-resistant tumors.

Cancer immunotherapy Chemoresistance breast cancer Platelet membrane fusion liposome Pyroptosis Type-I PDT

SCI

英语

其他

Outstanding Youths Development Scheme of Nanfang Hospital, Southern Medical University[2021J008] ; Science and Technology Projects in Guangzhou["2023A04J2370","202102020026"] ; GuangDong Basic and Applied Basic Research Foundation["2021A1515010022","2023A1515011787"] ; Launch Funding for Talent Introduction of Southern Medical University[R10101041]

Engineering

Engineering, Environmental ; Engineering, Chemical

WOS:001094395100001

ELSEVIER SCIENCE SA

ENGINEERING

2-s2.0-85175186610

Scopus

1.Department of General Surgery & Guangdong Provincial Key Laboratory of Precision Medicine for Gastrointestinal Tumor,Nanfang Hospital,The First School of Clinical Medicine,Southern Medical University,Guangzhou,Guangdong,510515,China
2.Department of Anesthesiology,Maternal and Child Health Hospital of Guangxi Zhuang Autonomous Region,Nanning,China
3.Department of Breast Surgery,Wuzhou Red Cross Hospital,Wuzhou,China
4.Department of Gastrointestinal Surgery & Department of Geriatrics,Shenzhen People's Hospital,The Second Clinical Medical College,Jinan University,The First Affiliated Hospital,Southern University of Science and Technology,Shenzhen,Guangdong,518020,China
5.Department of Plastic Surgery,Tongji Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,430030,China

Chen，Hao,Luo，Xi,Huang，Qinghua,et al. Platelet membrane fusion liposome loaded with type I AIE photosensitizer to induce chemoresistance cancer pyroptosis and immunogenic cell death for enhancing cancer immunotherapy[J]. Chemical Engineering Journal,2023,476.

Chen，Hao.,Luo，Xi.,Huang，Qinghua.,Liu，Zeming.,Lyu，Meng.,...&Zhu，Daoming.(2023).Platelet membrane fusion liposome loaded with type I AIE photosensitizer to induce chemoresistance cancer pyroptosis and immunogenic cell death for enhancing cancer immunotherapy.Chemical Engineering Journal,476.

Chen，Hao,et al."Platelet membrane fusion liposome loaded with type I AIE photosensitizer to induce chemoresistance cancer pyroptosis and immunogenic cell death for enhancing cancer immunotherapy".Chemical Engineering Journal 476(2023).