Cisplatin SERS Detection Based on the Binding of Sulfhydryl Groups

Chenlong Xue1; Jiaqi Hu1; Yanqun Xiang2; Junfan Chen1; Junyu Wei1; Jinqian Lv1; Aoyan Zhang1; Hong Dang1; Hao He1; Jie Hu1; Liyang Shao1; Gina Jinna Chen1; Zhen Gao1; Perry Ping Shum1

10.1109/OGC59456.2023.10314584

2023

979-8-3503-2533-1

2023 IEEE 8th Optoelectronics Global Conference (OGC)

148-151

5-8 Sept. 2023

Shenzhen, China

Cisplatin, a first-line anti-cancer drug, is widely utilized in clinical practice. Its anti-cancer mechanism involves DNA binding in the nucleus, leading to inhibition of cell division or induction of apoptosis. However, as heavy metal, platinum tends to accumulate in the body during metabolism and often results in nephrotoxicity, ototoxicity, and neurotoxicity. Therefore, developing an accurate cisplatin detection method is valuable for personalized treatment planning. In this study, we developed a novel p-amino thiophene (PATP) reaction-mediated surface-enhanced Raman scattering (SERS) assay for cisplatin detection. The Raman intensity of v (C-S) is linearly correlated with cisplatin concentration. This method is low-cost and convenient with high precision

SERS Raman Probe Cis-platinum Biosensing

第一

IEEE

1.Department of EEE, Key University Laboratory of Integrated Optoelectronics and Intellisense of Guangdong, Southern University of Science and Technology, Shenzhen, China
2.Department of Nasopharyngeal Carcinoma, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Center, the State Key Laboratory of Oncology in South China, Guangzhou, China

Chenlong Xue,Jiaqi Hu,Yanqun Xiang,et al. Cisplatin SERS Detection Based on the Binding of Sulfhydryl Groups[C],2023:148-151.