| 题名 | Regulated cell death in musculoskeletal formation, homeostasis, and diseases |
| 作者 | |
| 通讯作者 | Zengwu Shao; Guozhi Xiao |
| 共同第一作者 | Sheng Chen; Wenbo Yang; Mingjue Chen |
| 发表日期 | 2023-10-15
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| DOI | |
| 发表期刊 | |
| 摘要 | Regulated cell death (RCD) is a fundamental biological process that plays critical roles in regulating organogenesis and maintaining homeostasis under physiological conditions, and when cells are exposed to detrimental microenvironment, it contributes to the initiation and progression of pathological changes. Musculoskeletal disorders and diseases, such as osteoporosis, osteoarthritis, and intervertebral disc degeneration, have become public health problems worldwide, owing to their high prevalence and heavy economic burden. RCD is closely associated with the pathogenesis of skeletal disorders and diseases. Given the dedicated but controllable molecular machinery involved in RCD, studying the signal pathways and molecular mechanisms of RCD holds promise for the development of preventative and therapeutic targets. Over the last two decades, distinct modes and concepts of RCD have been proposed, including mitochondrial permeability transition-driven necrosis, lysosome-dependent cell death, pyroptosis, NETotic cell death, immunogenic cell death, necroptosis, entotic cell death, parthanatos, ferroptosis, autophagy-dependent cell death, alkaliptosis, oxeiptosis, PANoptosis, and cuproptosis. In this review, we aim to provide an up-to-date understanding of the roles of different RCD subroutines in maintaining the health and function of bones, cartilage and intervertebral discs. We will highlight their specific molecular mechanisms and cross-talks, hence offering valuable insights into further research directions. |
| 关键词 | |
| 收录类别 | |
| 语种 | 英语
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| 学校署名 | 通讯
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| 来源库 | 人工提交
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| 引用统计 | |
| 成果类型 | 期刊论文 |
| 条目标识符 | http://sustech.caswiz.com/handle/2SGJ60CL/610101 |
| 专题 | 南方科技大学医学院_生物化学系 南方科技大学医学院 |
| 作者单位 | 1.Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China. 2.Department of Biochemistry, School of Medicine, Shenzhen Key Laboratory of Cell Microenvironment, Guangdong Provincial Key Laboratory of Cell Microenvironment and Disease Research, Southern University of Science and Technology, Shenzhen 518055, China. |
| 通讯作者单位 | 生物化学系; 南方科技大学医学院 |
| 推荐引用方式 GB/T 7714 |
Sheng Chen,Wenbo Yang,Mingjue Chen,et al. Regulated cell death in musculoskeletal formation, homeostasis, and diseases[J]. Fundamental Research,2023.
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| APA |
Sheng Chen,Wenbo Yang,Mingjue Chen,Sheng Liu,Zengwu Shao,&Guozhi Xiao.(2023).Regulated cell death in musculoskeletal formation, homeostasis, and diseases.Fundamental Research.
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| MLA |
Sheng Chen,et al."Regulated cell death in musculoskeletal formation, homeostasis, and diseases".Fundamental Research (2023).
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| 条目包含的文件 | ||||||
| 文件名称/大小 | 文献类型 | 版本类型 | 开放类型 | 使用许可 | 操作 | |
| 160.Regulated cell d（2505KB） | -- | -- | 开放获取 | -- | 浏览 | |
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