Electrodeposition of Magnetic Alginate-poly-L-lysine Microcapsules for Targeted Drug Delivery

Niu，Jinchuan1; Liu，Zeyang2; Zhang，Hongyong1; Hu，Chengzhi1

10.1109/NEMS.2019.8915636

2019-04-01

2474-3747

2474-3755

978-1-7281-1630-3

Proceedings of the 14th Annual IEEE International Conference on Nano/Micro Engineered and Molecular Systems, NEMS 2019

403-408

11-14 April 2019

Bangkok, Thailand

345 E 47TH ST, NEW YORK, NY 10017 USA

Institute of Electrical and Electronics Engineers Inc.

In scenarios of targeted drug delivery, capsular drug micro-carriers need maintain drugs in a stable form to specific sites while avoiding the immunogenic and nonspecific interactions that efficiently clear foreign material from the body. Here, we present a facile method to synthesize magnetic drug micro-carriers by template-Assisted electrodeposition of alginate hydrogels on a patterned fluorine doped tin oxide (FTO) glass. The magnetic micro-hydrogel can be manipulated by external magnetic field. Electrodeposition of hydrogel is able to generate alginate gels in controlled shape and thickness. After the electrodeposition of alginate micro-carriers, poly-L-lysine (PLL) was coated on the alginate, with ferrite particles embedded inside the PLL membrane. The magnetic force generated by magnetic manipulation system is large and accurate enough to balance the fluid resistance and control microcapsules in three degrees of freedom. When the microcapsules reach the targeted site, specific solution was added to dissolve the alginate hydrogel and the encapsulated drugs can be released through PLL membrane to external environment. This magnetically driven hydrogel microcapsules can provide a non-Toxically, stable, high precision and high degrees of freedom way to achieve drug controlled release.

Alginate Drug delivery Magnetic manipulation Microcapsule

第一 ; 通讯

英语

EI ; CPCI-S

Engineering ; Science & Technology - Other Topics

Engineering, Electrical & Electronic ; Nanoscience & Nanotechnology

WOS:000521119700071

20195207894590

Alginate ; Amino acids ; Controlled drug delivery ; Degrees of freedom (mechanics) ; Drug delivery ; Electrodeposition ; Electrodes ; Hydrogels ; Magnetic fields ; Microstructure ; Nanocomposites ; Phase locked loops ; Tin oxides

Electroplating:539.3.1 ; Magnetism: Basic Concepts and Phenomena:701.2 ; Electronic Circuits Other Than Amplifiers, Oscillators, Modulators, Limiters, Discriminators or Mixers:713.5 ; Nanotechnology:761 ; Chemical Products Generally:804 ; Mechanics:931.1 ; Solid State Physics:933 ; Materials Science:951

2-s2.0-85076715186

Scopus

1.Southern University of Science and Technology,Department of Mechanical and Energy Engineering,Shenzhen,China
2.Tsinghua-Berkeley Shenzhen Institute (TBSI),Stem Cell Therapy and Regenerative Medicine Lab,Shenzhen,China

Niu，Jinchuan,Liu，Zeyang,Zhang，Hongyong,et al. Electrodeposition of Magnetic Alginate-poly-L-lysine Microcapsules for Targeted Drug Delivery[C]. 345 E 47TH ST, NEW YORK, NY 10017 USA:Institute of Electrical and Electronics Engineers Inc.,2019:403-408.