Gold Nanoclusters-Coated Orthodontic Devices Can Inhibit the Formation of Streptococcus mutans Biofilm

Xie，Yangzhouyun1,2; Zhang，Mengqi3; Zhang，Wei2; Liu，Xiaomo3; Zheng，Wenfu2; Jiang，Xingyu1,2

2020

10.1021/acsbiomaterials.9b01647

ACS Biomaterials Science and Engineering   影响因子和分区

23739878

2373-9878

Oral health is an issue that has attracted increasing attention recently. Poor oral hygiene may induce the formation of oral biofilm on orthodontic devices, and cause gingivitis and dental caries. Here, we present a strategy for modifying orthodontic devices (e.g., invisalign aligner) with quaternary ammonium (QA)-modified gold nanoclusters (QA-GNCs) as an antibiotic reagent to prevent bacterial contamination and biofilm formation. The QA-GNCs-coated aligner can efficiently inhibit the adhesion of cariogenic pathogenic Streptococcus mutans and the formation of biofilm. Moreover, the antibacterial activity of the coated QA-GNCs can be maintained for at least 3 months and after repeated usage (>3 cycles). Furthermore, the QA-GNCs coating shows excellent biosafety confirmed by the cell viability test, the hemolysis assay, and animal experiments. Our strategy for antibacterial coating has the advantages of broad applications, low cost, good stability, high antibacterial efficiency, good biocompatibility, and low risk of antibiotic contamination, which could be particularly useful in preventing infections involving implantable medical devices or wearable electronics.

aligner antibacterial coating antibiofilm gold nanoclusters

SCI ; EI

英语

第一

[2017YFA0205901] ; Chinese Academy of Sciences[QYZDJ-SSW-SLH039] ; National Natural Science Foundation of China[81673039]

Materials Science

Materials Science, Biomaterials

WOS:000513086900042

American Chemical Society

20200608143904

Antibiotics ; Biocompatibility ; Biofilms ; Nanoclusters

Medicine and Pharmacology:461.6 ; Immunology:461.9.1 ; Biomaterials (including synthetics):462.5 ; Nanotechnology:761 ; Coating Materials:813.2 ; Solid State Physics:933

2-s2.0-85079051437

Scopus

1.Department of Biomedical Engineering,Southern University of Science and Technology,Shenzhen, Guangdong,No. 1088 Xueyuan Road, Nanshan District,518055,China
2.Beijing Engineering Research Center for BioNanotechnology,CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety,CAS Center for Excellence in Nanoscience,National Center for NanoScience and Technology,Beijing,No. 11 Zhongguancun Beiyitiao,100190,China
3.Peking University School of Stomatology,Beijing,No. 22, Zhongguancun South Avenue, Haidian District,100081,China

Xie，Yangzhouyun,Zhang，Mengqi,Zhang，Wei,et al. Gold Nanoclusters-Coated Orthodontic Devices Can Inhibit the Formation of Streptococcus mutans Biofilm[J]. ACS Biomaterials Science and Engineering,2020,6(2):1239-1246.

Xie，Yangzhouyun,Zhang，Mengqi,Zhang，Wei,Liu，Xiaomo,Zheng，Wenfu,&Jiang，Xingyu.(2020).Gold Nanoclusters-Coated Orthodontic Devices Can Inhibit the Formation of Streptococcus mutans Biofilm.ACS Biomaterials Science and Engineering,6(2),1239-1246.

Xie，Yangzhouyun,et al."Gold Nanoclusters-Coated Orthodontic Devices Can Inhibit the Formation of Streptococcus mutans Biofilm".ACS Biomaterials Science and Engineering 6.2(2020):1239-1246.