Titanium Incorporation into Zr-Porphyrinic Metal–Organic Frameworks with Enhanced Antibacterial Activity against Multidrug-Resistant Pathogens

Chen，Mian1,2,3; Long，Zhou4; Dong，Ruihua2; Wang，Le2; Zhang，Jiangjiang2; Li，Sixiang5; Zhao，Xiaohui2; Hou，Xiandeng4; Shao，Huawu1; Jiang，Xingyu2,3,5

2020

10.1002/smll.201906240

Small   影响因子和分区

1613-6810

1613-6829

This study uses metal–organic frameworks (MOFs) alone without any added antibacterial ingredients as the nonantibiotic agent for photodynamic therapy (PDT) of chronic wounds infected by multidrug-resistant (MDR) bacteria. Nanoparticles (NPs) of MOFs (PCN-224) are incorporated with titanium through a facile cation exchange strategy. The obtained bimetallic PCN-224(Zr/Ti) shows greatly enhanced photocatalytic performance for the generation of reactive oxygen species under visible light, which is responsible for the effective antibacterial activities. The PCN-224(Zr/Ti) NPs are loaded onto lactic-co-glycolic acid nanofibers to prepare a wound dressing, which shows high biocompatibility and minimal cytotoxicity. The wound dressing is efficient for PDT-based in vivo healing of the chronic wound infected by MDR bacteria. Most importantly, this work does not involve any additional antibacterial agents, which is facile, low cost, and in particular, greatly explores the potential of MOFs as a powerful nonantibiotic agent in PDT.

MDR bacteria metal–organic frameworks photodynamic therapy titanium incorporation wound healing

SCI ; EI

英语

其他

[2017YFA0205901] ; Chinese Academy of Sciences[121D11KYSB20170026] ; National Natural Science Foundation of China[81730051]

Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics

Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter

WOS:000508508200001

Wiley-VCH Verlag

20200508112011

Bacteria ; Biocompatibility ; Nanofibers ; Photocatalytic activity ; Titanium

Medicine and Pharmacology:461.6 ; Immunology:461.9.1 ; Titanium and Alloys:542.3 ; Nanotechnology:761 ; Solid State Physics:933

2-s2.0-85078668092

Scopus

1.Natural Products Research Center,Chengdu Institute of Biology,Chinese Academy of Sciences,Chengdu,610041,China
2.Department of Biomedical Engineering,Southern University of Science and Technology,Shenzhen,No. 1088 Xueyuan Rd, Nanshan District,518055,China
3.University of Chinese Academy of Sciences,Beijing,19 A Yuquan Road, Shijingshan District,100049,China
4.Analytical & Testing Center,Sichuan University,Chengdu,610064,China
5.Beijing Engineering Research Center for BioNanotechnology and CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety,CAS Center for Excellence in Nanoscience,National Center for NanoScience and Technology,Beijing,No. 11 Zhongguancun Beiyitiao,100190,China

Chen，Mian,Long，Zhou,Dong，Ruihua,等. Titanium Incorporation into Zr-Porphyrinic Metal–Organic Frameworks with Enhanced Antibacterial Activity against Multidrug-Resistant Pathogens[J]. Small,2020,16(7).

Chen，Mian.,Long，Zhou.,Dong，Ruihua.,Wang，Le.,Zhang，Jiangjiang.,...&Jiang，Xingyu.(2020).Titanium Incorporation into Zr-Porphyrinic Metal–Organic Frameworks with Enhanced Antibacterial Activity against Multidrug-Resistant Pathogens.Small,16(7).

Chen，Mian,et al."Titanium Incorporation into Zr-Porphyrinic Metal–Organic Frameworks with Enhanced Antibacterial Activity against Multidrug-Resistant Pathogens".Small 16.7(2020).