Albumin Broadens the Antibacterial Capabilities of Nonantibiotic Small Molecule-Capped Gold Nanoparticles

Sun，Zhencheng1; Zheng，Wenshu2; Zhu，Guoshuai1; Lian，Jie3; Wang，Jidong3; Hui，Ping1; He，Songliang1; Chen，Wenwen1; Jiang，Xingyu4

2019-12-11

10.1021/acsami.9b15107

ACS Applied Materials & Interfaces   影响因子和分区

1944-8244

1944-8252

Nonantibiotic small molecule-modified gold nanoparticles (Au NPs) show great potential as an alternative for commercial antibiotics, yet their narrow antibacterial spectrum hinders the wide application in clinics. We observe that Au NPs cofunctionalized with both bovine serum albumin (BSA) and 4,6-diamino-2-pyrimidinethiol (DAPT) can generate conjugates (Au_DAPT_BSA) with progressive antimicrobial activities, including decreased minimal inhibitory concentration against Gram-negative bacteria and extended antibacterial spectrum against Gram-positive bacteria compared with DAPT-capped Au NPs (Au_DAPT). Au_DAPT_BSA induces no drug resistance and can significantly decrease the number of bacteria in the biofilms formed by Pseudomonas aeruginosa and Staphylococcus aureus. In addition, Au_DAPT_BSA exhibit in vivo healing efficiency for mice with subcutaneous abscesses caused by clinically isolated, multidrug resistant Escherichia coli or S. aureus without inducing detectable toxicity to the mammalian cells/animals. Our findings provide a new strategy for strengthening nanomaterial-based bactericides such as Au NPs, especially against drug-resistant bacterial infections.

bactericide drug-resistant infection gold nanoparticles non-antibiotic molecule protein

SCI ; EI

英语

其他

[JCYJ20170818144006925] ; Guangdong Medical Research Foundation[A2018154] ; National Natural Science Foundation of China[81701789] ; [2017001]

Science & Technology - Other Topics ; Materials Science

Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary

WOS:000502689000003

American Chemical Society

20194807764396

Antibiotics ; Bactericides ; Drug delivery ; Escherichia coli ; Fiber optic sensors ; Mammals ; Metal nanoparticles ; Molecules ; Proteins

Medicine and Pharmacology:461.6 ; Fiber Optics:741.1.2 ; Nanotechnology:761 ; Organic Compounds:804.1 ; Atomic and Molecular Physics:931.3

2-s2.0-85075692896

Scopus

1.Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging,School of Biomedical Engineering,Shenzhen University Health Science Center,Shenzhen,518055,China
2.National Center for NanoScience and Technology,Beijing,100190,China
3.Central Laboratory,Huazhong University of Science and Technology Union Shenzhen Hospital,Nanshan Hospital,Shenzhen Nanshan People's Hospital,6th Affiliated Hospital of Shenzhen University Health Science Center,Shenzhen,518052,China
4.Department of Biomedical Engineering,Southern University of Science and Technology,Shenzhen,518055,China

Sun，Zhencheng,Zheng，Wenshu,Zhu，Guoshuai,et al. Albumin Broadens the Antibacterial Capabilities of Nonantibiotic Small Molecule-Capped Gold Nanoparticles[J]. ACS Applied Materials & Interfaces,2019,11(49):45381-45389.

Sun，Zhencheng.,Zheng，Wenshu.,Zhu，Guoshuai.,Lian，Jie.,Wang，Jidong.,...&Jiang，Xingyu.(2019).Albumin Broadens the Antibacterial Capabilities of Nonantibiotic Small Molecule-Capped Gold Nanoparticles.ACS Applied Materials & Interfaces,11(49),45381-45389.

Sun，Zhencheng,et al."Albumin Broadens the Antibacterial Capabilities of Nonantibiotic Small Molecule-Capped Gold Nanoparticles".ACS Applied Materials & Interfaces 11.49(2019):45381-45389.