| 题名 | MircroRNA-92b as a negative regulator of the TGF-β signaling by targeting the type I receptor |
| 作者 | |
| 通讯作者 | Kang, Lin; Yang, Guangyan; Liang, Zhen |
| 发表日期 | 2023-11-17
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| DOI | |
| 发表期刊 | |
| EISSN | 2589-0042
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| 卷号 | 26期号:11 |
| 摘要 | Transforming growth factor beta 1 (TGF beta 1) has been identified as a major pathogenic factor underlying the development of chronic kidney disease (CKD). This study investigated the role of miR-92b-3p in the progression of renal fibrosis in unilateral ureteral occlusion (UUO) and unilateral ischemia-reperfusion injury (uIRI) mouse models, as well as explored its underlying mechanisms in human proximal tubular epithelial (HK2) cells. We found that renal fibrosis increased in UUO mice after miR-92b knockout, while it reduced in miR-92b overexpressing mice. MiR-92b knockout aggravated renal fibrosis in uIRI mice. RNA-sequencing analysis, the luciferase reporter assay, qPCR analysis, and western blotting confirmed that miR-92b-3p directly targeted TGF-beta receptor 1, thereby ameliorating renal fibrosis by suppressing the TGF-beta signaling pathway. Furthermore, we found that TGF-beta suppressed miR-92b transcription through Snail family transcriptional repressors 1 and 2. Our results suggest that miR-92b-3p may serve as a novel therapeutic for mitigating fibrosis in CKD. |
| 相关链接 | [来源记录] |
| 收录类别 | |
| 语种 | 英语
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| 学校署名 | 通讯
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| 资助项目 | National Natural Science Foundation of China["82370876","82170842","82371572","82171556"]
; Shenzhen Sustainable Development Science and Technology Special Project, China[KCXFZ20201221173600001]
; Key Program Topics of Shenzhen Basic Research, China[JCYJ20220818102605013]
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| WOS研究方向 | Science & Technology - Other Topics
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| WOS类目 | Multidisciplinary Sciences
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| WOS记录号 | WOS:001114197700001
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| 出版者 | |
| 来源库 | Web of Science
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| 引用统计 | |
| 成果类型 | 期刊论文 |
| 条目标识符 | http://sustech.caswiz.com/handle/2SGJ60CL/628955 |
| 专题 | 南方科技大学第一附属医院 |
| 作者单位 | 1.Jinan Univ, Shenzhen Peoples Hosp, Dept Geriatr, Clin Med Coll 2, Guangzhou, Peoples R China 2.Southern Univ Sci & Technol, Affiliated Hosp 1, Shenzhen 518000, Peoples R China 3.Jinan Univ, Shenzhen Peoples Hosp, Guangdong Prov Clin Res Ctr Geriatr, Shenzhen Clin Res Ctr Geriatr,Clin Med Coll 2, Guangzhou, Peoples R China 4.Southern Univ Sci & Technol, Affiliated Hosp 1, Shenzhen 518000, Peoples R China 5.Shenzhen Peoples Hosp, Biobank Natl Innovat Ctr Adv Med Devices, Shenzhen 518000, Peoples R China |
| 第一作者单位 | 南方科技大学第一附属医院 |
| 通讯作者单位 | 南方科技大学第一附属医院 |
| 推荐引用方式 GB/T 7714 |
Yang, Shu,Jiang, Kewei,Li, Lixing,et al. MircroRNA-92b as a negative regulator of the TGF-β signaling by targeting the type I receptor[J]. ISCIENCE,2023,26(11).
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| APA |
Yang, Shu.,Jiang, Kewei.,Li, Lixing.,Xiang, Jiaqing.,Li, Yanchun.,...&Liang, Zhen.(2023).MircroRNA-92b as a negative regulator of the TGF-β signaling by targeting the type I receptor.ISCIENCE,26(11).
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| MLA |
Yang, Shu,et al."MircroRNA-92b as a negative regulator of the TGF-β signaling by targeting the type I receptor".ISCIENCE 26.11(2023).
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| 条目包含的文件 | 条目无相关文件。 | |||||
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