南方科技大学知识苑(SUSTech KC): Small Antibodies with Big Applications: Nanobody-Based Cancer Diagnostics and Therapeutics

题名	Small Antibodies with Big Applications: Nanobody-Based Cancer Diagnostics and Therapeutics
作者	Zhang，Qian1 ; Zhang，Nan 2; Xiao，Han 3; Wang，Chen 1 ; He，Lian1
通讯作者	He，Lian
发表日期	2023-12-01
DOI	10.3390/cancers15235639
发表期刊	Cancers 影响因子和分区
EISSN	2072-6694
卷号	15 期号:23
摘要	Monoclonal antibodies (mAbs) have exhibited substantial potential as targeted therapeutics in cancer treatment due to their precise antigen-binding specificity. Despite their success in tumor-targeted therapies, their effectiveness is hindered by their large size and limited tissue permeability. Camelid-derived single-domain antibodies, also known as nanobodies, represent the smallest naturally occurring antibody fragments. Nanobodies offer distinct advantages over traditional mAbs, including their smaller size, high stability, lower manufacturing costs, and deeper tissue penetration capabilities. They have demonstrated significant roles as both diagnostic and therapeutic tools in cancer research and are also considered as the next generation of antibody drugs. In this review, our objective is to provide readers with insights into the development and various applications of nanobodies in the field of cancer treatment, along with an exploration of the challenges and strategies for their prospective clinical trials.
关键词	EGFR HER2 immunoPET NIR PD-L1 VHH
相关链接	[Scopus记录]
收录类别	SCI
语种	英语
学校署名	第一 ; 通讯
WOS记录号	WOS:001116071400001
Scopus记录号	2-s2.0-85178878434
来源库	Scopus
引用统计	被引频次[WOS]：4
成果类型	期刊论文
条目标识符	http://sustech.caswiz.com/handle/2SGJ60CL/628966
专题	南方科技大学医学院_药理学系南方科技大学医学院
作者单位	1.Department of Pharmacology,Joint Laboratory of Guangdong-Hong Kong Universities for Vascular Homeostasis and Diseases,School of Medicine,Southern University of Science and Technology,Shenzhen,518055,China 2.School of Biomedical Engineering,Guangzhou Medical University,Guangzhou,511436,China 3.Cuiying Biomedical Research Center,Lanzhou University Second Hospital,Lanzhou,730030,China
第一作者单位	药理学系; 南方科技大学医学院
通讯作者单位	药理学系; 南方科技大学医学院
第一作者的第一单位	药理学系; 南方科技大学医学院
推荐引用方式 GB/T 7714	Zhang，Qian,Zhang，Nan,Xiao，Han,et al. Small Antibodies with Big Applications: Nanobody-Based Cancer Diagnostics and Therapeutics[J]. Cancers,2023,15(23).
APA	Zhang，Qian,Zhang，Nan,Xiao，Han,Wang，Chen,&He，Lian.(2023).Small Antibodies with Big Applications: Nanobody-Based Cancer Diagnostics and Therapeutics.Cancers,15(23).
MLA	Zhang，Qian,et al."Small Antibodies with Big Applications: Nanobody-Based Cancer Diagnostics and Therapeutics".Cancers 15.23(2023).