Pathological progress and remission strategies of osteoarthritic lesions caused by long-term joint immobilization

Gan，Donghao1; Jin，Xiaowan1; Wang，Xiangpeng2; Tao，Chu1; Yan，Qinnan1; Jia，Qingyun3; Huo，Shaochuan4; Chen，Di5; Yao，Qing1; Xiao，Guozhi1

2023-12-01

10.1186/s13075-023-03223-3

Arthritis Research and Therapy   影响因子和分区

1478-6354

1478-6362

Objective: While joint immobilization is a useful repair method for intra-articular ligament injury and periarticular fracture, prolonged joint immobilization can cause multiple complications. A better understanding how joint immobilization and remobilization impact joint function and homeostasis will help clinicians develop novel strategies to reduce complications. Design: We first determined the effects of long-term immobilization on joint pain and osteophyte formation in patients after an extraarticular fracture or ligament injury. We then developed a mouse model of joint immobilization and harvested the knee joint samples at 2, 4, and 8 weeks. We further determined the effects of remobilization on recovery of the osteoarthritis (OA) lesions induced by immobilization in mice. Results: We found that the long-term (6 weeks) joint immobilization caused significant joint pain and osteophytes in patients. In mice, 2-week immobilization already induced moderate sensory innervation and increased pain sensitivity and infiltration in synovium without inducing marked osteophyte formation and cartilage loss. Long-term immobilization (4 and 8 weeks) induced more severe sensory innervation and inflammatory infiltration in synovium, massive osteophyte formation on both sides of the femoral condyle, and the edge of the tibial plateau and significant loss of the articular cartilage in mice. Remobilization, which ameliorates normal joint load and activity, restored to certain extent some of the OA lesions and joint function in mice. Conclusions: Joint immobilization caused multiple OA-like lesions in both mice and humans. Joint immobilization induced progressive sensory innervation, synovitis, osteophyte formation, and cartilage loss in mice, which can be partially ameliorated by remobilization.

Joint immobilization Osteoarthritis Osteophytes Remobilization Synovial invasion

SCI

英语

第一 ; 通讯

WOS:001116219300002

CLINICAL MEDICINE

2-s2.0-85178922673

Scopus

1.Department of Biochemistry,Guangdong Provincial Key Laboratory of Cell Microenvironment and Disease Research,Shenzhen Key Laboratory of Cell Microenvironment,School of Medicine,Southern University of Science and Technology,Shenzhen,China
2.First College of Clinical Medicine,Shandong University of Traditional Chinese Medicine,Jinan,China
3.Department of Orthopedics,Linyi People’s Hospital,Linyi,China
4.Shenzhen Hospital (Futian) of Guangzhou University of Chinese Medicine,Shenzhen,China
5.Research Center for Computer-Aided Drug Discovery,Shenzhen Institute of Advanced Technology,Chinese Academy of Sciences,Shenzhen,518055,China

Gan，Donghao,Jin，Xiaowan,Wang，Xiangpeng,et al. Pathological progress and remission strategies of osteoarthritic lesions caused by long-term joint immobilization[J]. Arthritis Research and Therapy,2023,25(1).

Gan，Donghao.,Jin，Xiaowan.,Wang，Xiangpeng.,Tao，Chu.,Yan，Qinnan.,...&Xiao，Guozhi.(2023).Pathological progress and remission strategies of osteoarthritic lesions caused by long-term joint immobilization.Arthritis Research and Therapy,25(1).

Gan，Donghao,et al."Pathological progress and remission strategies of osteoarthritic lesions caused by long-term joint immobilization".Arthritis Research and Therapy 25.1(2023).