In vivo optical imaging of reactive oxygen species (ROS)-related non-cancerous diseases

Gu，Wenxing1,2,3,4; Li，Shenhua3; Yang，Yajie3; Wang，Shumin3; Li，Kai1; Zhao，Yongsheng2; Mu，Jing2,3; Chen，Xiaoyuan4,5,6,7

2023-12-01

10.1016/j.trac.2023.117360

TrAC - Trends in Analytical Chemistry   影响因子和分区

0165-9936

1879-3142

The pathogenesis and progression of various diseases is highly related to the dysregulation of reactive oxygen species (ROS). In vivo optical imaging of ROS-relevant molecular events provides a valuable tool for non-invasive evaluation of the oxidative stress level and pathological alterations of human biological systems. Currently, involvement of ROS in the progression, angiogenesis and metastasis of cancer has been well documented, while comprehensive understanding of the roles of ROS in non-cancerous diseases are also essential for early disease diagnostics and evaluation of therapeutic response. In this review, we summarize recent advances in ROS-responsive probes for in vivo imaging and diagnosis of various physiological system diseases, including central nervous system diseases, respiratory system diseases, digestive system diseases, urinary system diseases, and other diseases. We highlight the design strategy, the mechanisms of ROS response and in vivo imaging studies, followed by discussions of the current challenges and perspectives in this field.

Fluorescence In vivo imaging Non-cancerous diseases Probe Reactive oxygen species

SCI ; EI

英语

第一

WOS:001112227800001

20234615070172

Diagnosis ; Fluorescence imaging ; Optical image storage ; Oxygen ; Respiratory system

Biological Materials and Tissue Engineering:461.2 ; Medicine and Pharmacology:461.6 ; Data Storage, Equipment and Techniques:722.1 ; Imaging Techniques:746 ; Chemical Products Generally:804

CHEMISTRY

2-s2.0-85176404990

Scopus

1.Shenzhen Key Laboratory of Smart Healthcare Engineering,Guangdong Provincial Key Laboratory of Advanced Biomaterials,Department of Biomedical Engineering,Southern University of Science and Technology,Shenzhen,518055,China
2.Department of Nuclear Medicine,Peking University Shenzhen Hospital,Shenzhen,518036,China
3.Institute of Precision Medicine,Peking University Shenzhen Hospital,Shenzhen,518036,China
4.Departments of Diagnostic Radiology,Surgery,Chemical and Biomolecular Engineering,and Biomedical Engineering,Yong Loo Lin School of Medicine and College of Design and Engineering,National University of Singapore,Singapore,119074,Singapore
5.Nanomedicine Translational Research Program,Yong Loo Lin School of Medicine,National University of Singapore,Singapore,117597,Singapore
6.Clinical Imaging Research Centre,Centre for Translational Medicine,Yong Loo Lin School of Medicine,National University of Singapore,Singapore,117599,Singapore
7.Institute of Molecular and Cell Biology,Agency for Science,Technology,and Research (A*STAR),61 Biopolis Drive, Proteos, Singapore,138673,Singapore

Gu，Wenxing,Li，Shenhua,Yang，Yajie,et al. In vivo optical imaging of reactive oxygen species (ROS)-related non-cancerous diseases[J]. TrAC - Trends in Analytical Chemistry,2023,169.

Gu，Wenxing.,Li，Shenhua.,Yang，Yajie.,Wang，Shumin.,Li，Kai.,...&Chen，Xiaoyuan.(2023).In vivo optical imaging of reactive oxygen species (ROS)-related non-cancerous diseases.TrAC - Trends in Analytical Chemistry,169.

Gu，Wenxing,et al."In vivo optical imaging of reactive oxygen species (ROS)-related non-cancerous diseases".TrAC - Trends in Analytical Chemistry 169(2023).