南方科技大学知识苑(SUSTech KC): Association study for the role of MMP8 gene polymorphisms in Colorectal cancer susceptibility

题名	Association study for the role of MMP8 gene polymorphisms in Colorectal cancer susceptibility
作者	Yu，Shuyong 1; Cheng，Jiajia 1; Li，Ping 2; Tian，Le 2; Chen，Zhuang 3; Chen，Zhaowei 3; Li，Yongyu 3; Song，Jian 4
通讯作者	Song，Jian
发表日期	2023-12-01
DOI	10.1186/s12885-023-11662-z
发表期刊	BMC Cancer 影响因子和分区
EISSN	1471-2407
卷号	23 期号:1
摘要	Background: Colorectal cancer (CRC) is one of the most common malignant tumors, influenced by several genetic loci in its clinical phenotypes. The aim of this study was to determine the relationship between the MMP8 gene polymorphism and CRC risk in the Chinese Han population. Method: This study recruited 688 CRC patients and 690 healthy controls. The relationship between MMP8 polymorphism and CRC susceptibility was assessed by calculating the odds ratio (OR) and 95% confidence interval (CI) after stratifying by age, gender, body mass index (BMI), smoking, and alcohol consumption under a multi-genetic model. Results: MMP8 rs3740938 was associated with increased CRC predisposition (p = 0.016, OR = 1.24, 95% CI: 1.04–1.48), and this association was detected particularly in subjects aged > 60 years, females, people with BMI > 24 kg/m, smokers, and drinkers. Moreover, rs3740938 was found to be associated with the pathological type of rectal cancer. Conclusions: Our results first displayed that rs3740938 in MMP8 was a risk factor for CRC predisposition. This finding may provide a new biological perspective for understanding the role of the MMP8 gene in CRC pathogenesis.
关键词	Colorectal cancer MMP8 polymorphisms Stratification analysis Susceptibility
相关链接	[Scopus记录]
收录类别	SCI
语种	英语
学校署名	通讯
WOS记录号	WOS:001111050700002
ESI学科分类	CLINICAL MEDICINE
Scopus记录号	2-s2.0-85177858519
来源库	Scopus
引用统计	被引频次[WOS]：1
成果类型	期刊论文
条目标识符	http://sustech.caswiz.com/handle/2SGJ60CL/628996
专题	南方科技大学医院
作者单位	1.Department of Gastrointestinal Surgery IV,Hainan Cancer Hospital,Haikou,Hainan,570100,China 2.Department of Digestive Endoscopy,Hainan Cancer Hospital,Haikou,Hainan,570100,China 3.Department of Gastroenterology,Hainan Cancer Hospital,Haikou,Hainan,570100,China 4.Department of Gastroenterology,Southern University of Science and Technology Hospital,Shenzhen,No. 6019 Liuxian Avenue, Nanshan District, Guangdong,518000,China
通讯作者单位	南方科技大学医院
推荐引用方式 GB/T 7714	Yu，Shuyong,Cheng，Jiajia,Li，Ping,et al. Association study for the role of MMP8 gene polymorphisms in Colorectal cancer susceptibility[J]. BMC Cancer,2023,23(1).
APA	Yu，Shuyong.,Cheng，Jiajia.,Li，Ping.,Tian，Le.,Chen，Zhuang.,...&Song，Jian.(2023).Association study for the role of MMP8 gene polymorphisms in Colorectal cancer susceptibility.BMC Cancer,23(1).
MLA	Yu，Shuyong,et al."Association study for the role of MMP8 gene polymorphisms in Colorectal cancer susceptibility".BMC Cancer 23.1(2023).