Clinical characteristics and predictors for cardiovascular system involvement in patients with Behçet's disease

Deng, Z.1; Wang, X.1; Li, T.1,2; Lyu, C.1,2; Li, J.2,3; Liu, H.2,3

2023-10-01

CLINICAL AND EXPERIMENTAL RHEUMATOLOGY   影响因子和分区

0392-856X

1593-098X

ObjectiveThe purpose of this study is to analyse the clinical characteristics of Behcet's disease (BD) patients in China with or without cardiovascular system involvement, and to develop a risk model to identify factors related to cardiovascular involvement in BD.MethodsThis retrospective cohort study, using the information on BD in Shenzhen People's Hospital from January 2000 to December 2021, included 95 patients: BD patients without cardiovascular system involvement (n=63) and with cardiovascular system involvement (n=32).ResultsPatients with BD who were males and had a combination of hypertension and a longer duration of disease were more likely to have cardiovascular involvement (p < 0.05). Compared to patients without cardiovascular involvement, mani-festations of genital ulcers are rarely observed in those with cardiovascular involvement (60.32% vs. 37.50%, p=0.035). The binary logistic regression analysis found that ascending aortic widening and a history of hypertension were independent risk factors for BD with cardiovascular system involvement (OR=1.277, 95% CI 1.09, 1.495, p=0.002; OR=11.578, 95% CI 1.308, 102.639, p=0.028). The established prediction model indicated that can help to predict the likelihood of cardiovascular involvement in a patient with BD.ConclusionCardiovascular involvement in BD is not at all rare, however, it is often underreported due to a lack of specificity. BD patients who are male, have a history of combined hypertension, and have a long duration of disease should be focused on the presence of combined cardiovascular system involvement, with particular attention to the patient's ascending aortic internal diameter.

Behcet's disease cardiac involvement cardiovascular system involvement clinical characteristics risk factors

SCI

英语

通讯

Shenzhen People's Hospital Research Cultivation Project["SYJCYJ202014","SYLCYJ202119"] ; Sanming Project of Medicine in Shenzhen[SZSM201412012] ; Shenzhen Key Medical Discipline Construction Fund[szxk003] ; Science and Technology Planning Project of Shenzhen Municipality[JCYJ20190806153207263]

Rheumatology

Rheumatology

WOS:001098661500003

CLINICAL & EXPER RHEUMATOLOGY

CLINICAL MEDICINE

Web of Science

1.Jinan Univ, Clin Med Coll 2, Shenzhen, Guangdong, Peoples R China
2.Southern Univ Sci Technol, Shenzhen Peoples Hosp, Clin Med Coll 2, Shenzhen Cardiovasc Minimally Invas Med Engn Techn, Shenzhen, Guangdong, Peoples R China
3.Southern Univ Sci & Technol, Jinan Univ, Dept Cardiol, Clin Med Coll 2,First Affiliated Hosp 1,Shenzhen P, 1017 Dongmen North Rd, Shenzhen 518020, Guangdong, Peoples R China

Deng, Z.,Wang, X.,Li, T.,et al. Clinical characteristics and predictors for cardiovascular system involvement in patients with Behçet's disease[J]. CLINICAL AND EXPERIMENTAL RHEUMATOLOGY,2023,41(10).

Deng, Z.,Wang, X.,Li, T.,Lyu, C.,Li, J.,&Liu, H..(2023).Clinical characteristics and predictors for cardiovascular system involvement in patients with Behçet's disease.CLINICAL AND EXPERIMENTAL RHEUMATOLOGY,41(10).

Deng, Z.,et al."Clinical characteristics and predictors for cardiovascular system involvement in patients with Behçet's disease".CLINICAL AND EXPERIMENTAL RHEUMATOLOGY 41.10(2023).