Employing Noble Metal-Porphyrins to Engineer Robust and Highly Active Single-Atom Nanozymes for Targeted Catalytic Therapy in Nasopharyngeal Carcinoma

Wang, Daji1; Wang, Jie1,2; Gao, Xuejiao J.3; Ding, Hui2; Yang, Ming4; He, Zhiheng5; Xie, Jiaying5; Zhang, Zixia5; Huang, Haibing2; Nie, Guohui2; Yan, Xiyun1,5,6; Fan, Kelong1,5,6

2023-12-01

10.1002/adma.202310033

ADVANCED MATERIALS   影响因子和分区

0935-9648

1521-4095

["Single-atom nanozymes (SANzymes) emerge as promising alternatives to conventional enzymes. However, chemical instability limits their application. Here, a systematic synthesis of highly active and stable SANzymes is presented by leveraging noble metal-porphyrins. Four noble metal-porphyrins are successfully synthesized to mimic the active site of natural peroxidases through atomic metal-N coordination anchored to the porphyrin center. These noble metal-porphyrins are integrated into a stable and biocompatible Zr-based metal-organic framework (MxP, x denoting Ir, Ru, Pt, and Pd). Among these, MIrP demonstrates superior peroxidase-like activity (685.61 U mg-1), catalytic efficiency, and selectivity compared to horseradish peroxidase (267.71 U mg-1). Mechanistic investigations unveil heightened catalytic activity of MIrP arises from its robust H2O2 adsorption capacity, unique rate-determining step, and low energy threshold. Crucially, MIrP exhibits remarkable chemical stability under both room temperature and high H2O2 concentrations. Further, through modification with (-)-Epigallocatechin-3-Gallate, a natural ligand for Epstein-Barr virus (EBV)-encoded latent membrane protein 1, targeted SANzyme (MIrPHE) tailored for EBV-associated nasopharyngeal carcinoma is engineered. This study not only presents an innovative strategy for augmenting the catalytic activity and chemical stability of SANzymes but also highlights the substantial potential of MIrP as a potent nanomedicine for targeted catalytic tumor therapy.","A series of noble metal-porphyrins based MOFs (MxP, x denoting Ir, Ru, Pt, and Pd) is prepared to fabricate highly active and stable single-atom nanozymes (SANzymes). Among these, MIrP demonstrates excellent peroxidase-like activity (685.61 U mg-1) and chemical stability. Through modification with (-)-Epigallocatechin-3-Gallate, a targeted SANzyme tailored for EBV-associated nasopharyngeal carcinoma is engineered.image"]

nasopharyngeal carcinoma noble metal-porphyrins peroxidase-like activity single-atom nanozymes targeted catalytic therapy

SCI ; EI

英语

NI论文

其他

National Key Research and Development Program of China[2021YFC2102900] ; Chinese Academy of Sciences Project for Young Scientists in Basic Research[YSBR-089] ; Natural Science Foundation of Guangdong Province["2021A1515110028","2022A1515220147","2023A1515030210"] ; Science and Technology Program for Basic Research in Shenzhen["JCYJ20210324103015039","JCYJ20190809095811254","JCYJ20200109140412476","JCYJ20190806163814395","JCYJ20210324103203010","JCYJ20210324120011030","JSGG20220606141001002"] ; Medical science and technology research in Guangdong Province[A2022078] ; Sanming Project of Medicine in Shenzhen[SZSM201612031] ; null[32200744] ; null[82122037] ; null[82003303] ; null[82102205]

Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics

Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter

WOS:001114976700001

WILEY-V C H VERLAG GMBH

MATERIALS SCIENCE

Web of Science

1.Chinese Acad Sci, Shenzhen Inst Synthet Biol, Shenzhen Inst Adv Technol, Nanozyme Synth Ctr,Key Lab Quantitat Synthet Biol, Shenzhen 518055, Peoples R China
2.Shenzhen Univ, Shenzhen Peoples Hosp 2, Affiliated Hosp 1, Hlth Sci Ctr,Shenzhen Key Lab Nanozymes & Translat, Shenzhen 518035, Peoples R China
3.Jiangxi Normal Univ, Coll Chem & Chem Engn, Nanchang 330022, Peoples R China
4.Southern Univ Sci & Technol, Jinan Univ, Shenzhen Peoples Hosp, Affiliated Hosp 1,Clin Med Coll 2,Dept Otolaryngol, Shenzhen 518020, Peoples R China
5.Chinese Acad Sci, Inst Biophys, CAS Engn Lab Nanozyme, Key Lab Biomacromolecules, Beijing 100101, Peoples R China
6.Zhengzhou Univ, Sch Basic Med Sci, Nanozyme Med Ctr, Zhengzhou 450001, Peoples R China

Wang, Daji,Wang, Jie,Gao, Xuejiao J.,et al. Employing Noble Metal-Porphyrins to Engineer Robust and Highly Active Single-Atom Nanozymes for Targeted Catalytic Therapy in Nasopharyngeal Carcinoma[J]. ADVANCED MATERIALS,2023.

Wang, Daji.,Wang, Jie.,Gao, Xuejiao J..,Ding, Hui.,Yang, Ming.,...&Fan, Kelong.(2023).Employing Noble Metal-Porphyrins to Engineer Robust and Highly Active Single-Atom Nanozymes for Targeted Catalytic Therapy in Nasopharyngeal Carcinoma.ADVANCED MATERIALS.

Wang, Daji,et al."Employing Noble Metal-Porphyrins to Engineer Robust and Highly Active Single-Atom Nanozymes for Targeted Catalytic Therapy in Nasopharyngeal Carcinoma".ADVANCED MATERIALS (2023).