Systematic proteomics profiling of lysine crotonylation of the lung at Pseudoglandular and Canalicular phases in human fetus

Wang，Wei1; Shi，Wei2; Wang，Yinglan2; Yang，Yane3; Li，Ping3; Zeng，Zhipeng1; Hu，Wenlong1; Chen，Yumei1; Tang，Donge1; Dai，Yong1

2023-12-01

10.1186/s12953-023-00215-8

Proteome Science   影响因子和分区

1477-5956

Lung tissue is an important organ of the fetus, and genomic research on its development has improved our understanding of the biology of this tissue. However, the proteomic research of developing fetal lung tissue is still very scarce. We conducted comprehensive analysis of two developmental stages of fetal lung tissue of proteomics. It showed the developmental characteristics of lung tissue, such as the down-regulation of metabolism-related protein expression, the up-regulation of cell cycle-related proteins, and the regulation in proteins and pathways related to lung development. In addition, we also discovered some key core proteins related to lung development, and provided some key crotonylation modification sites that regulation during lung tissue development. Our comprehensive analysis of lung proteomics can provide a more comprehensive understanding of the developmental status of lung tissue, and provide a certain reference for future research and epigenetics of lung tissue.

Bioinformatics Epigenetics Lung development Lysine crotonylation Proteomics

SCI

英语

第一 ; 通讯

WOS:001112069100001

2-s2.0-85178181710

Scopus

1.Clinical Medical Research Center,Guangdong Provincial Engineering Research Center of Autoimmune Disease Precision Medicine,Shenzhen Engineering Research Center of Autoimmune Disease,The Second Clinical Medical College of Jinan University,The First Affiliated Hospital Southern University of Science and Technology,ShenzhenPeople’s Hospital,Shenzhen,Guangdong,518020,China
2.Department of Obstetrics and Gynecology,The Second Clinical Medical College of Jinan University,The First Affiliated Hospital Southern,University of Science and Technology,ShenzhenPeople’s Hospital,Shenzhen,Guangdong,518020,China
3.Shenzhen Far East Women & Children Hospital,Shenzhen,Guangdong,518000,China

Wang，Wei,Shi，Wei,Wang，Yinglan,et al. Systematic proteomics profiling of lysine crotonylation of the lung at Pseudoglandular and Canalicular phases in human fetus[J]. Proteome Science,2023,21(1).

Wang，Wei.,Shi，Wei.,Wang，Yinglan.,Yang，Yane.,Li，Ping.,...&Dai，Yong.(2023).Systematic proteomics profiling of lysine crotonylation of the lung at Pseudoglandular and Canalicular phases in human fetus.Proteome Science,21(1).

Wang，Wei,et al."Systematic proteomics profiling of lysine crotonylation of the lung at Pseudoglandular and Canalicular phases in human fetus".Proteome Science 21.1(2023).