Bromine Substitution Improves the Photothermal Performance of Ï -Conjugated Phototheranostic Molecules

Wan, Feiyan1; Wang, Huan2,3; Gu, Ying2,3; Fan, Guilin1; Hou, Shengxin1; Yu, Jiantao1; Wang, Mengying1; He, Feng2,3; Tian, Leilei1

2023-12-01

10.1002/chem.202303502

CHEMISTRY-A EUROPEAN JOURNAL   影响因子和分区

0947-6539

1521-3765

["NIR-II fluorescence imaging-guided photothermal therapy (PTT) has been widely investigated due to its great application potential in tumor theranostics. PTT is an effective and non-invasive tumor treatment method that can adapt to tumor hypoxia; nevertheless, simple and effective strategies are still desired to develop new materials with excellent PTT properties to meet clinical requirements. In this work, we developed a bromine-substitution strategy to enhance the PTT of A-D-A'-D-A pi-conjugated molecules. The experimental results reveal that bromine substitution can notably enhance the absorptivity (epsilon) and photothermal conversion efficiency (PCE) of the pi-conjugated molecules, resulting in the brominated molecules generating two times more heat (epsilon 808 nmxPCE) than their unsubstituted counterpart. We disclose that the enhanced photothermal properties of bromine-substituted pi-conjugated molecules are a combined outcome of the heavy-atom effect, enhanced ICT effect, and more intense bromine-mediate intermolecular pi-pi stacking. Finally, the NIR-II tumor imaging capability and efficient PTT tumor ablation of the brominated pi-conjugated materials demonstrate that bromine substitution is a promising strategy for developing future high-performance NIR-II imaging-guided PTT agents.","Bromine substitution enhances the photothermal properties of pi-conjugated phototheranostic molecules; this is the outcome of a combination of the heavy-atom effect, enhanced ICT effect, and more intense bromine-mediate intermolecular pi-pi stacking. The results demonstrate that bromine substitution is promising for developing high-performance NIR-II imaging-guided photothermal agents.image"]

bromine substitution pi-conjugated molecules NIR-II fluorescence imaging photothermal therapy tumor treatment

SCI ; EI

英语

第一 ; 通讯

Shenzhen Fundamental Research Programs[JCYJ20220530113612027] ; Shenzhen Science and Technology Innovation Commission[KQTD20170810111314625] ; null[51973089]

Chemistry

Chemistry, Multidisciplinary

WOS:001112986800001

WILEY-V C H VERLAG GMBH

20234915164514

Bromine ; Conversion efficiency ; Infrared devices ; Molecules ; Tumors

Biological Materials and Tissue Engineering:461.2 ; Energy Conversion Issues:525.5 ; Imaging Techniques:746 ; Inorganic Compounds:804.2 ; Atomic and Molecular Physics:931.3

CHEMISTRY

2-s2.0-85178434970

Web of Science

1.Southern Univ Sci & Technol China, Dept Mat Sci & Engn, Shenzhen 518055, Guangdong, Peoples R China
2.Southern Univ Sci & Technol, Shenzhen Grubbs Inst, Guangdong Prov Key Lab Catalysis, Shenzhen 518055, Guangdong, Peoples R China
3.Southern Univ Sci & Technol, Dept Chem, Shenzhen 518055, Guangdong, Peoples R China

Wan, Feiyan,Wang, Huan,Gu, Ying,et al. Bromine Substitution Improves the Photothermal Performance of Ï -Conjugated Phototheranostic Molecules[J]. CHEMISTRY-A EUROPEAN JOURNAL,2023,30(5).

Wan, Feiyan.,Wang, Huan.,Gu, Ying.,Fan, Guilin.,Hou, Shengxin.,...&Tian, Leilei.(2023).Bromine Substitution Improves the Photothermal Performance of Ï -Conjugated Phototheranostic Molecules.CHEMISTRY-A EUROPEAN JOURNAL,30(5).

Wan, Feiyan,et al."Bromine Substitution Improves the Photothermal Performance of Ï -Conjugated Phototheranostic Molecules".CHEMISTRY-A EUROPEAN JOURNAL 30.5(2023).