In Vitro Detection of S100B and Severity Evaluation of Traumatic Brain Injury Based on Biomimetic Peptide-Modified Nanochannels

Zhang, Wenyuan1,2,3; Zhang, Jianrui1; Wang, Yijun1; Wang, Senyao1; Wu, Yitian1; Zhang, Wenchang3; Wu, Minghui1; Wang, Li1; Xu, Guoheng1; Deng, Fuan1; Liu, Wenchao1; Liu, Zhengwei2,3; Chen, Lu4; Xiao, Kai1; Zhang, Lu1

2023-11-01

10.1002/smll.202306809

SMALL   影响因子和分区

1613-6810

1613-6829

["The diagnosis and evaluation of traumatic brain injury (TBI) are crucial steps toward the treatment and prognosis of patients. A common question remains as to whether it is possible to introduce an ideal device for signal detection and evaluation that can directly connect digital signals with TBI, thereby enabling prompt response of the evaluation signal and sensitive and specific functioning of the detection process. Herein, a method is presented utilizing polymetric porous membranes with TRTK-12 peptide-modified nanochannels for the detection of S100B (a TBI biomarker) and assessment of TBI severity. The method leverages the specific bonding force between TRTK-12 peptide and S100B protein, along with the nanoconfinement effect of nanochannels, to achieve high sensitivity (LOD: 0.002 ng mL-1) and specificity ( increment I/I0: 44.7%), utilizing ionic current change as an indicator. The proposed method, which is both sensitive and specific, offers a simple yet responsive approach for real-time evaluation of TBI severity. This innovative technique provides valuable scientific insights into the advancement of future diagnostic and therapeutic integration devices.","Here a method for detecting S100B (Traumatic brain injury biomarker) concentration to evaluate TBI severity is reported, which uses polymetric porous membrane with TRTK-12 peptide-modified nanochannels. This method exhibits high sensitivity, high specificity, and simply effective real-time response. It anticipates broad implications in future medical-grade comprehensive tests and assessment of disease extent.image"]

nanochannels nanofluidic peptide S100B detection traumatic brain injury

SCI ; EI

英语

第一 ; 通讯

Guangdong Provincial Key Laboratory of Advanced Biomaterials[2022B1212010003] ; National Natural Science Foundation of China["22275079","52273129"] ; Shenzhen Science and Technology Innovation Committee["20220815164834003","20220530114405013"] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDB36000000] ; Shenzhen Science and Technology Program[KQTD 20221101093559017] ; null[2023YFC2415900]

Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics

Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter

WOS:001108811800001

WILEY-V C H VERLAG GMBH

20234815120494

Biomimetics ; Brain ; Diagnosis ; Nanofluidics ; Patient treatment

Biomedical Engineering:461.1 ; Medicine and Pharmacology:461.6 ; Biotechnology:461.8 ; Biology:461.9 ; Nanofluidics:632.5.2 ; Nanotechnology:761

Web of Science

1.Southern Univ Sci & Technol, Dept Biomed Engn, Guangdong Prov Key Lab Adv Biomat, Shenzhen 518055, Peoples R China
2.Guangzhou Univ Chinese Med, Shenzhen Clin Med Coll, Shenzhen 518000, Peoples R China
3.Longgang Cent Hosp Shenzhen, Dept Neurosurg, Shenzhen 518116, Peoples R China
4.Shenzhen Polytech, Sch Mat & Environm Engn, Shenzhen 518055, Peoples R China

Zhang, Wenyuan,Zhang, Jianrui,Wang, Yijun,et al. In Vitro Detection of S100B and Severity Evaluation of Traumatic Brain Injury Based on Biomimetic Peptide-Modified Nanochannels[J]. SMALL,2023.

Zhang, Wenyuan.,Zhang, Jianrui.,Wang, Yijun.,Wang, Senyao.,Wu, Yitian.,...&Zhang, Lu.(2023).In Vitro Detection of S100B and Severity Evaluation of Traumatic Brain Injury Based on Biomimetic Peptide-Modified Nanochannels.SMALL.

Zhang, Wenyuan,et al."In Vitro Detection of S100B and Severity Evaluation of Traumatic Brain Injury Based on Biomimetic Peptide-Modified Nanochannels".SMALL (2023).