Efficacy and Safety of Probiotics in Geriatric Patients with Constipation: Systematic Review and Meta-Analysis

Deng, X.1,2,3; Shang, X.4; Zhou, L.1,2,3; Li, X.1,2,3; Guo, K.5; Xu, M.1,2,3; Hou, L.1,2,3; Hui, X.1,2,3; Li, Shuangping6

2023-11-01

10.1007/s12603-023-2028-4

JOURNAL OF NUTRITION HEALTH & AGING   影响因子和分区

1279-7707

1760-4788

BackgroundProbiotics may be an effective alternative to traditional drug therapy for constipation in the elderly.ObjectiveTo assess the efficacy and safety of probiotics in managing constipation among the elderly.MethodsEight databases were queried for randomized controlled trials (RCTs) investigating probiotics' efficacy in addressing constipation among the elderly until January 2023. The meta-analysis was conducted employing R software version 4.2.2. The Cochrane risk of bias tool was utilized to evaluate the risk of bias, and the GRADE approach was employed to assess the credibility of the evidence concerning the efficacy of probiotics in treating constipation in older individuals.ResultsA total of six RCTs involving 444 patients were included. Two studies were rated as low risk of bias. The meta-analysis findings revealed that probiotics, when compared to a placebo, led to an increase in stool frequency (MD = 1.02,95% CI [0.21, 2.07], p<0.05, very low quality), the probiotic group exhibited a notable impact on ameliorating symptoms associated with constipation (OR = 11.28, 95%CI [7.21, 17.64], p < 0.05, very low quality), no significant disparities were observed in terms of efforts to evacuate, manual maneuvers, and the incidence of adverse events (p>0.05).ConclusionThe available evidence indicates a degree of uncertainty, ranging from low-to-very low, suggesting the efficacy of probiotics in augmenting bowel frequency and ameliorating constipation-related symptoms among elderly patients with constipation. Nevertheless, given the quality of the studies included, it is advisable to conduct further well-designed investigations with substantial sample sizes to substantiate the findings of this study.

Probiotics elderly constipation meta-analysis

SCI

英语

其他

Natural Science Foundation of Gansu Province[18JR3RA062]

Geriatrics & Gerontology ; Nutrition & Dietetics

Geriatrics & Gerontology ; Nutrition & Dietetics

WOS:001106538700004

SPRINGER FRANCE

Web of Science

1.Lanzhou Univ, Hlth Technol Assessment Ctr, Evidence Based Social Sci Res Ctr, Sch Publ Hlth, Lanzhou, Peoples R China
2.Lanzhou Univ, Evidence Based Med Ctr, Sch Basic Med Sci, Lanzhou, Peoples R China
3.Key Lab Evidence Based Med & Knowledge Translat, Lanzhou 730000, Gansu, Peoples R China
4.Southern Univ Sci & Technol, Sch Publ Hlth & Emergency Management, Shenzhen, Peoples R China
5.Gansu Prov Canc Hosp, Dept Radiol, 2 Xiaoxihu East St, Lanzhou 730000, Gansu, Peoples R China
6.Gansu Prov Canc Hosp, Lanzhou, Peoples R China

Deng, X.,Shang, X.,Zhou, L.,et al. Efficacy and Safety of Probiotics in Geriatric Patients with Constipation: Systematic Review and Meta-Analysis[J]. JOURNAL OF NUTRITION HEALTH & AGING,2023.

Deng, X..,Shang, X..,Zhou, L..,Li, X..,Guo, K..,...&Li, Shuangping.(2023).Efficacy and Safety of Probiotics in Geriatric Patients with Constipation: Systematic Review and Meta-Analysis.JOURNAL OF NUTRITION HEALTH & AGING.

Deng, X.,et al."Efficacy and Safety of Probiotics in Geriatric Patients with Constipation: Systematic Review and Meta-Analysis".JOURNAL OF NUTRITION HEALTH & AGING (2023).