NIR-II Photoacoustic Imaging-Guided Oxygen Delivery and Controlled Release Improves Photodynamic Therapy for Hepatocellular Carcinoma

Zeng, Silue1,2,3; Chen, Jingqin2; Gao, Rongkang2; Chen, Rui4; Xue, Qiang2,5; Ren, Yaguang2; Liu, Liangjian2; Tang, Chuanyu1,3; Hu, Haoyu1,3; Zeng, Ning1,3; Wen, Sai1,3; Zhang, Hai5; Liu, Chengbo2; Fang, Chihua1,3

2023-12-01

10.1002/adma.202308780

ADVANCED MATERIALS   影响因子和分区

0935-9648

1521-4095

["Hypoxia, a prominent hallmark of hepatocellular carcinoma (HCC), undermines curative outcomes, elevates recurrence rates, and fosters metastasis, particularly during photodynamic therapy (PDT) in clinical settings. Studies indicate that alleviating tumor hypoxia enhances PDT efficacy. However, persistent challenges, including suboptimal oxygen delivery efficiency and absence of real-time feedback on blood oxygen fluctuations during PDT, considerably impede therapeutic efficacy in tumor treatment. This study addresses these issues using near-infrared-II (NIR-II) photoacoustic (PA) imaging for tumor-targeted oxygen delivery and controlled release. For this purpose, a biomimetic oxygen delivery system designated BLICP@O2 is developed, which utilizes hybrid tumor cell membranes and thermosensitive liposomes as oxygen carriers, incorporating the NIR-II dye IR1048, photosensitizer chlorin e6 (Ce6), and perfluorohexane. Upon sequential irradiation at 1064 and 690 nm, BLICP@O2 exhibits significant photothermal and photodynamic effects. Photothermal heating triggers oxygen release, enhancing the photodynamic effect of Ce6. Blood oxygen changes during PDT are tracked by multispectral PA imaging. Enhanced PDT efficacy, mediated by hypoxia relief, is convincingly demonstrated both in vitro and in vivo. This work presents an imaging-guided, dual-wavelength programmed cascaded treatment strategy for tumor-targeted oxygen delivery and controlled release, with real-time efficacy monitoring using PA imaging, offering valuable insights for overcoming challenges in PDT-based cancer therapy.","This work develops a new theranostic strategy for photoacoustic (PA)-guided oxygen delivery, controlled release, and photodynamic therapy (PDT). The strategy demonstrates precise thermal-triggered oxygen release in situ of tumor, evaluated by real-time multispectral PA imaging of blood oxygen levels during PDT. This developed strategy, assisted by near-infrared-II PA imaging, provides a novel approach for hepatocellular carcinoma treatment and therapeutic monitoring.image"]

hepatocellular carcinoma photoacoustic imaging oxygen controlled release photodynamic therapy

SCI ; EI

英语

其他

National Natural Science Foundation of China (NSFC)["82122034","92059108","81927807","81627805","12026602","82172008","62105355"] ; NSFC-GD Union Foundation[U1401254] ; Chinese Academy of Sciences Grant (Youth Innovation Promotion Association)["2019352","2023374","YJKYYQ20190078","GJJSTD20210003"] ; Shenzhen Science and Technology Innovation Grant["JCYJ20220818101403008","JCYJ20200109141222892","JCYJ20220531100409023","JCYJ20210324101403010"] ; CAS Key Laboratory of Health Informatics[2011DP173015] ; Guangdong Provincial Key Laboratory of Biomedical Optical Imaging[2020B121201010] ; Shenzhen Key Laboratory for Molecular Imaging[ZDSY20130401165820357] ; Science and Technology Program of Guangzhou[2023A04J2415] ; null[2021YFE0202200] ; null[2022YFE0132300] ; null[2020YFA0908800] ; null[2016YFC0106500]

Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics

Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter

WOS:001112603800001

WILEY-V C H VERLAG GMBH

MATERIALS SCIENCE

Web of Science

1.Southern Med Univ, Zhujiang Hosp, Gen Surg Ctr, Dept Hepatobiliary Surg 1, Guangzhou 510280, Peoples R China
2.Chinese Acad Sci, Shenzhen Inst Adv Technol, Res Ctr Biomed Opt & Mol Imaging, Key Lab Biomed Imaging Sci & Syst, Shenzhen 518055, Peoples R China
3.Guangdong Prov Clin & Engn Ctr Digital Med, Guangzhou 510280, Peoples R China
4.Sichuan Univ, Biliary Surg Dept, West China Hosp, Chengdu 610064, Sichuan, Peoples R China
5.Jinan Univ, Southern Univ Sci & Technol, Shenzhen Peoples Hosp, Affiliated Hosp 1,Dept Ultrasound,Clin Coll 2, Shenzhen 518020, Peoples R China

Zeng, Silue,Chen, Jingqin,Gao, Rongkang,et al. NIR-II Photoacoustic Imaging-Guided Oxygen Delivery and Controlled Release Improves Photodynamic Therapy for Hepatocellular Carcinoma[J]. ADVANCED MATERIALS,2023.

Zeng, Silue.,Chen, Jingqin.,Gao, Rongkang.,Chen, Rui.,Xue, Qiang.,...&Fang, Chihua.(2023).NIR-II Photoacoustic Imaging-Guided Oxygen Delivery and Controlled Release Improves Photodynamic Therapy for Hepatocellular Carcinoma.ADVANCED MATERIALS.

Zeng, Silue,et al."NIR-II Photoacoustic Imaging-Guided Oxygen Delivery and Controlled Release Improves Photodynamic Therapy for Hepatocellular Carcinoma".ADVANCED MATERIALS (2023).