Longitudinal reciprocal association between rheumatoid arthritis and chronic obstructive pulmonary disease and mediation of inflammation

Yang, Kai1; Wang, Lingwei1; Chen, Shuyu1; Chen, Rongchang1,2

2023-11-01

10.1093/rheumatology/kead594

RHEUMATOLOGY   影响因子和分区

1462-0324

1462-0332

Objectives: To elucidate the longitudinal reciprocal association between rheumatoid arthritis (RA) and chronic obstructive pulmonary disease (COPD), and the mediating role of systemic inflammation in the association.Methods: 403045 participants from UK Biobank were enrolled in this study. A cross-lagged panel model was used to investigate the longitudinal reciprocal association between RA and COPD. Cox-proportional hazard regression and logistic regression models were also conducted to examine the association between baseline RA and COPD during follow-up, and vice versa. Causal mediation analysis was then performed to explore the mediating roles of 160 systemic inflammatory biomarkers in the bidirectional association.Results: At baseline, 4755 (1.2%) and 6989 (1.7%) individuals were diagnosed with RA and COPD, respectively. After adjusting for the covariates, the result of cross-lagged panel model revealed a bidirectional association between RA and COPD (beta = 0.018, P < 0.001 for RA -> COPD path; beta = 0.010, P < 0.001 for COPD -> RA path). In the non-COPD population, the risk of future COPD was increased in RA patients (Cox: HR = 1.65, 95% CI, 1.50-1.83; logistic: OR = 1.85, 95% CI, 1.66-2.07). In the non-RA population, baseline COPD was associated with a higher risk of RA during follow-up (Cox: HR = 1.67, 95% CI, 1.44-1.92; logistic: OR = 1.70, 95% CI, 1.47-1.97). Five inflammatory factors mediated the RA -> COPD path, and C-reactive protein mediated the COPD -> RA path (FDR < 0.05).Conclusions: A significant bidirectional association exists between RA and COPD, and it is partially mediated by systemic inflammation.

rheumatoid arthritis chronic obstructive pulmonary disease systemic inflammation bidirectional association causal mediation

SCI

英语

第一 ; 通讯

National Natural Science Foundation of China[97223]

Rheumatology

Rheumatology

WOS:001109973100001

OXFORD UNIV PRESS

CLINICAL MEDICINE

Web of Science

1.Southern Univ Sci & Technol, Clin Med Coll 2, Shenzhen Peoples Hosp, Affiliated Hosp 1,Jinan Univ,Shenzhen Inst Resp Di, Shenzhen, Peoples R China
2.Southern Univ Sci & Technol, Clin Med Coll 2, Shenzhen Peoples Hosp, Affiliated Hosp 1,Jinan Univ,Shenzhen Inst Resp Di, Shenzhen 518001, Peoples R China

Yang, Kai,Wang, Lingwei,Chen, Shuyu,et al. Longitudinal reciprocal association between rheumatoid arthritis and chronic obstructive pulmonary disease and mediation of inflammation[J]. RHEUMATOLOGY,2023.

Yang, Kai,Wang, Lingwei,Chen, Shuyu,&Chen, Rongchang.(2023).Longitudinal reciprocal association between rheumatoid arthritis and chronic obstructive pulmonary disease and mediation of inflammation.RHEUMATOLOGY.

Yang, Kai,et al."Longitudinal reciprocal association between rheumatoid arthritis and chronic obstructive pulmonary disease and mediation of inflammation".RHEUMATOLOGY (2023).