| 题名 | Vincristine exposure impairs mouse oocyte quality by inducing spindle defects and early apoptosis |
| 作者 | |
| 通讯作者 | Zhang, Chunhui; Qian, Weiping; Li, Jian |
| 发表日期 | 2023-11-01
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| DOI | |
| 发表期刊 | |
| ISSN | 1521-6543
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| EISSN | 1521-6551
|
| 摘要 | Vincristine (VCR) is a microtubule-destabilizing chemotherapeutic agent commonly administered for the treatment of cancers in patients, which can induce severe side effects including neurotoxicity. In context of the effects on female fertility, ovarian toxicity has been found in patients and mice model after VCR exposure. However, the influence of VCR exposure on oocyte quality has not been elucidated. We established VCR exposure in vitro and in vivo model. The results indicated in vitro VCR exposure contributed to failure of oocyte maturation through inducing defects in spindle assembly, activation of SAC, oxidative stress, mitochondrial dysfunction, and early apoptosis, which were confirmed by using in vivo exposure model. Moreover, in vivo VCR exposure caused aneuploidy, reduced oocyte-sperm binding ability, and the number of cortical granules in mouse oocyte cortex. Taken together, this study demonstrated that VCR could cause meiotic arrest and poor quality of mouse oocyte. |
| 关键词 | |
| 相关链接 | [来源记录] |
| 收录类别 | |
| 语种 | 英语
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| 学校署名 | 其他
|
| WOS研究方向 | Biochemistry & Molecular Biology
; Cell Biology
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| WOS类目 | Biochemistry & Molecular Biology
; Cell Biology
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| WOS记录号 | WOS:001108648200001
|
| 出版者 | |
| ESI学科分类 | BIOLOGY & BIOCHEMISTRY
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| 来源库 | Web of Science
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| 引用统计 | |
| 成果类型 | 期刊论文 |
| 条目标识符 | http://sustech.caswiz.com/handle/2SGJ60CL/629128 |
| 专题 | 南方科技大学医学院 南方科技大学医学院_人类细胞生物和遗传学系 |
| 作者单位 | 1.Peking Univ, Dept Reprod Med, Shenzhen Hosp, Shenzhen, Peoples R China 2.Peking Univ, Tianjin Cent Hosp 5, Dept Gen Surg, Binhai Hosp, Tianjin, Peoples R China 3.Southern Univ Sci & Technol, Sch Med, Dept Human Cell Biol & Genet, Shenzhen, Peoples R China 4.Peking Univ, Shenzhen Hosp, Dept Reprod Med, Shenzhen 518036, Guangdong, Peoples R China |
| 推荐引用方式 GB/T 7714 |
Chang, Haoya,Cheng, Siyu,Xing, Guoqiang,et al. Vincristine exposure impairs mouse oocyte quality by inducing spindle defects and early apoptosis[J]. IUBMB LIFE,2023.
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| APA |
Chang, Haoya.,Cheng, Siyu.,Xing, Guoqiang.,Huang, Chenyang.,Zhang, Chunhui.,...&Li, Jian.(2023).Vincristine exposure impairs mouse oocyte quality by inducing spindle defects and early apoptosis.IUBMB LIFE.
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| MLA |
Chang, Haoya,et al."Vincristine exposure impairs mouse oocyte quality by inducing spindle defects and early apoptosis".IUBMB LIFE (2023).
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| 条目包含的文件 | 条目无相关文件。 | |||||
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