Comorbidity of Myasthenia gravis and Graves' disease as immune reconstitution-associated autoimmune disease in HIV infection: A case report and literature review

Lu, Lianfeng1; Ma, Yanan1; Cong, Yang1; Zhou, Baotong1; Chen, Yeye1; Niu, Jingwen1; He, Yun2; Cao, Wei1,5; Li, Taisheng1,3,4

2023-11-01

10.1111/hiv.13584

HIV MEDICINE   影响因子和分区

1464-2662

1468-1293

Background: Comorbidity of Myasthenia gravis (MG) and Graves' disease (GD) in treated HIV-infected individuals has rarely been described and little study has been done on the link between HIV-related immune reconstitution and autoimmune diseases occurring post antiretroviral therapy.Case Presentation: Here we report on a 33-year-old Chinese man with HIV infection who had been virologically suppressed since 2018. The patient was diagnosed with GD and was treated in 2020. Early in 2022, he developed fluctuating weakness and fatigue involving the bilateral extraocular muscles and limbs. With a positive neostigmine test, he was considered to have MG, but showed a poor response to oral medication. After multiple failed medication attempts, a thymectomy was finally performed to resolve his symptoms. The consecutive onset of immunological events may have partially resulted from immune reconstitution after viral control.Conclusions: This is a rare case of HIV-related immune reconstitution-associated autoimmune disease (IRAD) with comorbidity of MG and GD which was reported initially. Cooperation with multidisciplinary teams is essential to avoid misdiagnosis and to promote the overall health of HIV-infected patients.

ART Graves' disease HIV immune reconstitution-associated autoimmune disease myasthenia gravis

SCI

英语

其他

Infectious Diseases

Infectious Diseases

WOS:001108076200001

WILEY

IMMUNOLOGY

Web of Science

1.Peking Union Med Coll & Chinese Acad Med Sci, Peking Union Med Coll Hosp, Beijing, Peoples R China
2.Southern Univ Sci & Technol, Peoples Hosp Shenzhen 3, Affiliated Hosp 2, Dept Infect Dis, Shenzhen, Peoples R China
3.Tsinghua Univ, Sch Med, Dept Basic Med Sci, Beijing, Peoples R China
4.Chinese Acad Med Sci & Peking Union Med Coll, Peking Union Med Coll Hosp, State Key Lab Complex Severe & Rare Dis, Beijing, Peoples R China
5.Peking Union Med Coll & Chinese Acad Med Sci, Peking Union Med Coll Hosp, Dept Infect Dis, 1 Shuai Fu Yuan, Beijing 100730, Peoples R China

Lu, Lianfeng,Ma, Yanan,Cong, Yang,et al. Comorbidity of Myasthenia gravis and Graves' disease as immune reconstitution-associated autoimmune disease in HIV infection: A case report and literature review[J]. HIV MEDICINE,2023.

Lu, Lianfeng.,Ma, Yanan.,Cong, Yang.,Zhou, Baotong.,Chen, Yeye.,...&Li, Taisheng.(2023).Comorbidity of Myasthenia gravis and Graves' disease as immune reconstitution-associated autoimmune disease in HIV infection: A case report and literature review.HIV MEDICINE.

Lu, Lianfeng,et al."Comorbidity of Myasthenia gravis and Graves' disease as immune reconstitution-associated autoimmune disease in HIV infection: A case report and literature review".HIV MEDICINE (2023).