Building a Better Silver Bullet: Current Status and Perspectives of Non-Viral Vectors for mRNA Vaccines

Gu, Jiayu1,2; Xu, Zhourui2; Liu, Qiqi2,3; Tang, Shiqi2; Zhang, Wenguang2; Xie, Shouxia1,4; Chen, Xiaoyan3; Chen, Jiajie5; Yong, Ken-Tye6; Yang, Chengbin2; Xu, Gaixia2

2023-11-01

10.1002/adhm.202302409

ADVANCED HEALTHCARE MATERIALS   影响因子和分区

2192-2640

2192-2659

["In recent years, messenger RNA (mRNA) vaccines have exhibited great potential to replace conventional vaccines owing to their low risk of insertional mutagenesis, safety and efficacy, rapid and scalable production, and low-cost manufacturing. With the great achievements of chemical modification and sequence optimization methods of mRNA, the key to the success of mRNA vaccines is strictly dependent on safe and efficient gene vectors. Among various delivery platforms, non-viral mRNA vectors could represent perfect choices for future clinical translation regarding their safety, sufficient packaging capability, low immunogenicity, and versatility. In this review, the recent progress in the development of non-viral mRNA vectors is focused on. Various organic vectors including lipid nanoparticles (LNPs), polymers, peptides, and exosomes for efficient mRNA delivery are presented and summarized. Furthermore, the latest advances in clinical trials of mRNA vaccines are described. Finally, the current challenges and future possibilities for the clinical translation of these promising mRNA vectors are also discussed.","This review has focused on up-to-date development of non-viral vectors for mRNA Vaccine. The advantages and disadvantages of various mRNA vector are commented and discussed. Meanwhile, the ongoing clinical trials of various mRNA vector are also summarized. The prospect of clinical transformation of various mRNA vectors are highlighted.image"]

gene therapy lipid nanoparticles mRNA delivery mRNA vaccines snon-viral vector

SCI ; EI

英语

第一

J.G. and Z.X. contributed equally to this work. This work was financially supported by the National Natural Science Foundation of China (62205216, 82201851, 82204526), the Natural Science Foundation of Guangdong Province (2021A1515012159), Basic Research F["62205216","82201851","82204526"] ; National Natural Science Foundation of China[2021A1515012159] ; Natural Science Foundation of Guangdong Province[JCYJ20220531101814034] ; Basic Research Foundation of Shenzhen[SZXK059] ; Shenzhen Key Medical Discipline Construction Fund[SYJCYJ202103] ; Shenzhen Peopleapos;s Hospital Backbone Breeding Project of Young and Middle-aged Scientific Researchers[SYJCYJ202103] ; middle-aged technical backbone research and cultivation project of Shenzhen Peopleapos;s Hospital[Z04JKM2021005]

Engineering ; Science & Technology - Other Topics ; Materials Science

Engineering, Biomedical ; Nanoscience & Nanotechnology ; Materials Science, Biomaterials

WOS:001101656100001

WILEY

2-s2.0-85176297526

Web of Science

1.Southern Univ Sci & Technol, Dept Pharm, Shenzhen Peoples Hosp, Affiliated Hosp 1,Clin Med Coll 2,Jinan Univ, Shenzhen 518020, Peoples R China
2.Shenzhen Univ, Sch Biomed Engn, Guangdong Key Lab Biomed Measurements & Ultrasound, Med Sch, Shenzhen 518060, Peoples R China
3.Shenzhen Baoan Womens & Childrens Hosp, Maternal Fetal Med Inst, Dept Obstet & Gynaecol, Shenzhen 518102, Peoples R China
4.Shenzhen Peoples Hosp, Shenzhen Clin Res Ctr Geriatr, Shenzhen 518020, Peoples R China
5.Shenzhen Univ, Sch Basic Med Sci, Dept Biochem & Mol Biol, Med Sch, Shenzhen 518060, Peoples R China
6.Univ Sydney, Sch Biomed Engn, Sydney, NSW 2006, Australia

Gu, Jiayu,Xu, Zhourui,Liu, Qiqi,et al. Building a Better Silver Bullet: Current Status and Perspectives of Non-Viral Vectors for mRNA Vaccines[J]. ADVANCED HEALTHCARE MATERIALS,2023,13(3).

Gu, Jiayu.,Xu, Zhourui.,Liu, Qiqi.,Tang, Shiqi.,Zhang, Wenguang.,...&Xu, Gaixia.(2023).Building a Better Silver Bullet: Current Status and Perspectives of Non-Viral Vectors for mRNA Vaccines.ADVANCED HEALTHCARE MATERIALS,13(3).

Gu, Jiayu,et al."Building a Better Silver Bullet: Current Status and Perspectives of Non-Viral Vectors for mRNA Vaccines".ADVANCED HEALTHCARE MATERIALS 13.3(2023).