| 题名 | Tumor cell-derived exosomes mediating hsa_circ_0001739/lncRNA AC159540.1 facilitate liver metastasis in colorectal cancer |
| 作者 | |
| 通讯作者 | Guo, Yun-Miao |
| 发表日期 | 2023-11-01
|
| DOI | |
| 发表期刊 | |
| ISSN | 0742-2091
|
| EISSN | 1573-6822
|
| 摘要 | BackgroundThe current study probed into how tumor cell-derived exosomes (Exos) mediated hsa_circ_0001739/lncRNA AC159540.1 to manipulate microRNA (miR)-218-5p/FTO-N6-methyladenosine (m6A)/MYC signal axis in liver metastasis in colorectal cancer (CRC).Methodshsa_circ_0001739 and lncRNA AC159540.1 were identified as the upstream regulator of miR-218-5p using ENCORI and LncBase databases. Expression patterns of miR-218-5p, hsa_circ_0001739, lncRNA AC159540.1, FTO, and MYC were detected, accompanied by loss-and-gain-of function assays to examine their effects on CRC cell biological functions. SW480 cells-derived Exos were purified, followed by in vitro studies to uncover the effect of hsa_circ_0001739/lncRNA AC159540.ResultsmiR-218-5p was downregulated while hsa_circ_0001739/lncRNA AC159540.1 was upregulated in CRC tissues and cells. Silencing of hsa_circ_0001739/lncRNA AC159540.1 restrained the malignant phenotypes of CRC cells. Exos-mediated hsa_circ_0001739/lncRNA AC159540.1 competitively inhibited miR-218-5p to elevate FTO and MYC. The inducing role of Exos-mediated hsa_circ_0001739/lncRNA AC159540.1 in CRC was also validated in vivo.ConclusionConclusively, Exos-mediated circ_0001739/lncRNA AC159540.1 regulatory network is critical for CRC, offering a theoretical basis for CRC treatment. |
| 关键词 | |
| 相关链接 | [来源记录] |
| 收录类别 | |
| 语种 | 英语
|
| 学校署名 | 其他
|
| 资助项目 | National Natural Science Foundation of China["82002866","82072384","81602416","81602691"]
; Guangdong Basic and Applied Basic Research Foundation[2023A1515030063]
|
| WOS研究方向 | Cell Biology
; Toxicology
|
| WOS类目 | Cell Biology
; Toxicology
|
| WOS记录号 | WOS:001101101000001
|
| 出版者 | |
| ESI学科分类 | MOLECULAR BIOLOGY & GENETICS
|
| 来源库 | Web of Science
|
| 引用统计 | |
| 成果类型 | 期刊论文 |
| 条目标识符 | http://sustech.caswiz.com/handle/2SGJ60CL/629197 |
| 专题 | 南方科技大学第一附属医院 |
| 作者单位 | 1.Guangdong Med Univ, Zhanjiang Cent Hosp, Cent Peoples Hosp Zhanjiang, Dept Lab Med, Zhanjiang 524045, Peoples R China 2.Southern Univ Sci & Technol, Jinan Univ, Shenzhen Peoples Hosp, Dept Oncol,Affiliated Hosp 1,Clin Med Coll 2, Shenzhen 518020, Peoples R China 3.Guangzhou Med Univ, Prenatal Diagnost Ctr & Cord Blood Bank, Guangzhou Women & Childrens Med Ctr, Guangzhou 510623, Peoples R China 4.Sun Yat Sen Univ, Affiliated Hosp 1, Dept Lab Med, Guangzhou 510080, Peoples R China 5.Guangdong Acad Med Sci, Guangdong Prov Peoples Hosp, Dept Lab Med, Guangzhou 510080, Peoples R China 6.Guangdong Med Univ, Cent Peoples Hosp Zhanjiang, Dept Cardiovasc Diag, Zhanjiang Cent Hosp, Zhanjiang 524045, Peoples R China 7.Guangdong Med Univ, Zhanjiang Cent Hosp, Cent Peoples Hosp Zhanjiang, Zhanjiang Inst Clin Med, Zhanjiang 524045, Peoples R China |
| 推荐引用方式 GB/T 7714 |
Yue, Cai-Feng,Chen, Ju-Gao,Li, Zi-Yue,et al. Tumor cell-derived exosomes mediating hsa_circ_0001739/lncRNA AC159540.1 facilitate liver metastasis in colorectal cancer[J]. CELL BIOLOGY AND TOXICOLOGY,2023.
|
| APA |
Yue, Cai-Feng.,Chen, Ju-Gao.,Li, Zi-Yue.,Li, Lai-Sheng.,Chen, Jie-Rong.,...&Guo, Yun-Miao.(2023).Tumor cell-derived exosomes mediating hsa_circ_0001739/lncRNA AC159540.1 facilitate liver metastasis in colorectal cancer.CELL BIOLOGY AND TOXICOLOGY.
|
| MLA |
Yue, Cai-Feng,et al."Tumor cell-derived exosomes mediating hsa_circ_0001739/lncRNA AC159540.1 facilitate liver metastasis in colorectal cancer".CELL BIOLOGY AND TOXICOLOGY (2023).
|
| 条目包含的文件 | 条目无相关文件。 | |||||
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。
修改评论