Trajectories and risk factors of persistent cough after pulmonary resection: A prospective two-center study

Sun, Xuefeng1,2,3; Lan, Zihua2,4; Li, Shaopeng1,2,5; Huang, Shujie2,4; Zeng, Cheng1,2; Wu, Junhan2,4; Chen, Qibin2,6; Chen, Yizhang1,2; Chen, Ziguo1,2; Tang, Yong2,7; Qiao, Guibin1,2,4,7

2023-11-01

10.1111/1759-7714.15147

THORACIC CANCER   影响因子和分区

1759-7706

1759-7714

Background: Persistent cough is one of the most frequent complications following lung cancer surgery. To promote optimal recovery, we conducted a study to investigate the trajectories of coughing symptoms and their impact on quality of life (QOL), as well as to identify potential risk factors of persistent cough after pulmonary resection (CAP).Methods: This prospective observational study assessed patients who underwent pulmonary resection for lung tumor at two medical centers in China. Persistent CAP was evaluated before surgery, at discharge, and 1, 3, and 6 months following surgery using visual analog scale (VAS), cough symptom score (CSS), and Leicester Cough Questionnaire in Mandarin Chinese (LCQ-MC). Univariate and multivariate logistic regression analyses were conducted to explore independent risk factors for persistent CAP.Results: Of the 506 enrolled patients, 130 patients were diagnosed with persistent CAP with an incidence of 25.69%. Compared to the noncough group, patients with persistent CAP reported significantly higher VAS (p < 0.001) and CSS scores (p < 0.001) and experienced worse QOL (p < 0.001) for up to 6 months, particularly at 1 month following surgery. Multivariable regression analysis revealed that a duration of anesthesia exceeding 156 min (odds ratio [OR]: 1.847, 95% confidence interval [CI]: 1.156-2.951, p = 0.010) and gastroesophageal acid reflux (GER) (OR: 3.870, 95% CI: 2.376-6.304, p < 0.001) were independent risk factors of persistent CAP.Conclusion: Patients who suffer from persistent CAP face a substantial burden and diminished QOL for an extended period compared to noncough patients. Moreover, prolonged duration of anesthesia and postoperative GER are potential risk factors of persistent CAP.

lung cancer persistent cough pulmonary resection risk factor trajectory

SCI

英语

其他

Natural Science Foundation of Guangdong Province[2022A1515012469] ; Popularization of Science and Technology Innovation Special Project of Guangdong Province[2020A1414070007] ; Science and Technology Program of Guangdong[210716126901104] ; Science and Technology Program of Guangzhou["201704020107","202206010103"]

Oncology ; Respiratory System

Oncology ; Respiratory System

WOS:001098000600001

WILEY

2-s2.0-85175695760

Web of Science

1.Southern Med Univ, Sch Clin Med 2, Guangzhou, Peoples R China
2.Southern Med Univ, Guangdong Prov Peoples Hosp, Guangdong Acad Med Sci, Dept Thorac Surg, Guangzhou, Peoples R China
3.Jinan Univ, Southern Univ Sci & Technol, Shenzhen Peoples Hosp, Affiliated Hosp 1,Clin Med Coll 2,Dept Thorac Surg, Shenzhen, Peoples R China
4.Shantou Univ, Med Coll, Shantou, Peoples R China
5.Longgang Cent Hosp Shenzhen, Dept Thorac Surg, Shenzhen, Peoples R China
6.Guangdong Acad Med Sci, Guangdong Prov Peoples Hosp, Guangdong Cardiovasc Inst, Guangzhou, Peoples R China
7.Southern Med Univ, Guangdong Prov Peoples Hosp, Guangdong Acad Med Sci, Dept Thorac Surg, 106 Zhongshan 2nd Rd, Guangzhou 510080, Peoples R China

Sun, Xuefeng,Lan, Zihua,Li, Shaopeng,et al. Trajectories and risk factors of persistent cough after pulmonary resection: A prospective two-center study[J]. THORACIC CANCER,2023,14(36):3503-3510.

Sun, Xuefeng.,Lan, Zihua.,Li, Shaopeng.,Huang, Shujie.,Zeng, Cheng.,...&Qiao, Guibin.(2023).Trajectories and risk factors of persistent cough after pulmonary resection: A prospective two-center study.THORACIC CANCER,14(36),3503-3510.

Sun, Xuefeng,et al."Trajectories and risk factors of persistent cough after pulmonary resection: A prospective two-center study".THORACIC CANCER 14.36(2023):3503-3510.