Histopathological features of glandular atrophy of the lamina propria of the gastric mucosa during its occurrence and development

Wang，Yang kun1; Ran，Dong mei2; Li，Ying ying3; Zhu，Chao ya4; Zhang，Ren bing5; Jiang，Bo6; Wang，Su nan3

2023-12-01

10.1186/s12876-023-03033-6

BMC Gastroenterology   影响因子和分区

1471-230X

Objective: To explore the histopathological features of glandular atrophy of the lamina propria of gastric mucosa during its occurrence and development. Method: We performed detailed histological observation and immunohistochemical examination on the endoscopic biopsy and ESD endoscopic resection specimens of 896 patients with glandular atrophy of the lamina propria of gastric mucosa. The EnVision two-step method was used for immunohistochemical staining, and the slices were incubated with primary antibody CK7, CK20, villin, CDX2, MUC5AC, MUC6, p53 and ki-67. Hematoxylin staining was performed and observed under the microscope and statistically analyzed. Results: In the initial stage of glandular atrophy of the lamina propria, the proliferation area of the deep gastric pits, and the isthmus and neck of the gastric glands are characterized by roughly normal structure of the glandular structure, increased mesenchyme, and widened space between glands. Subsequently, the gland becomes smaller in volume and less in number, especially at the base, in the gastric glandular part of the gastric unit. The disease at this stage has higher incidence, and occurs more often in the elderly who account for 64.0% (573/896) of our study group. The disease in this stage may exhibit some lesions that are physiologic (age-related degeneration) while others are pathological. Therefore, this condition is called simple glandular atrophy of the lamina propria of the gastric mucosa. When the gastric mucosal epithelium is subjected to infection or repeated infections, chemical stimuli, immune factors, and genetic factors, it can lead to the proliferation and transformation of stem cells in the proliferation area of the deep gastric pits, and the isthmus and neck of the gastric glands, forming single ducts, multiple ducts, or a proliferation of patchy cells. Then, atypical hyperplasia (intraepithelial neoplasia) presents, finally leading to gastric adenocarcinoma. Conclusion: Understanding the histopathological characteristics of glandular atrophy of the lamina propria of gastric mucosa is of great significance in controlling the occurrence and development of gastric cancer.

Gastric adenocarcinoma Gastric mucosal atrophy Histopathology Immunohistochemistry Intraepithelial neoplasia

SCI

英语

其他

WOS:001102220400001

CLINICAL MEDICINE

2-s2.0-85176788644

Scopus

1.Department of Pathology,The Fourth People’s Hospital of Longgang District,Shenzhen,518123,China
2.Department of Pathology,Southern University of Science and Technology Hospital,Shenzhen,518055,China
3.Shenzhen Polytechnic,Shenzhen,Xili Lake, Xilihu Town, Nanshan District, Guangdong,518055,China
4.Third Affiliated Hospital of Zhengzhou University,Shenzhen,450052,China
5.Department of Pathology,Shenzhen Longgang District People’s Hospital,Shenzhen,518172,China
6.Department of Pathology,No. 990 Hospital of the PLA Joint Logistics Support Force,Zhumadian,463000,China

Wang，Yang kun,Ran，Dong mei,Li，Ying ying,et al. Histopathological features of glandular atrophy of the lamina propria of the gastric mucosa during its occurrence and development[J]. BMC Gastroenterology,2023,23(1).

Wang，Yang kun.,Ran，Dong mei.,Li，Ying ying.,Zhu，Chao ya.,Zhang，Ren bing.,...&Wang，Su nan.(2023).Histopathological features of glandular atrophy of the lamina propria of the gastric mucosa during its occurrence and development.BMC Gastroenterology,23(1).

Wang，Yang kun,et al."Histopathological features of glandular atrophy of the lamina propria of the gastric mucosa during its occurrence and development".BMC Gastroenterology 23.1(2023).