Active Breathing Coordinator reduces radiation dose to the stomach in patients with left breast cancer

Piao, Ying1,2; Chen, Hongtao1,2; Yuan, Fengshun3; Fan, Juan1,2; Wu, Shihai1,2; Li, Xianming1,2; Yang, Dong1,2

2023-10-01

10.1080/0284186X.2023.2275288

ACTA ONCOLOGICA   影响因子和分区

0284-186X

1651-226X

Background/purpose: Gastric dose parameters comparison for deep inspiration breath-hold (DIBH) or free breathing (FB) mode during radiotherapy (RT) for left-sided breast cancer patients (LSBCPs) has not been investigated before. This study aimed to analyze the impact of Active Breath Coordinator (ABC)-DIBH technique on the dose received by the stomach during RT for LSBCPs and to provide organ-specific dosimetric parameters.Materials and methods: The study included 73 LSBCPs. The dosimetric parameters of the stomach were compared between FB and DIBH mode. The correlation between the stomach volume and dosimetric parameters was analyzed.Results: Compared to FB mode, statistically significant reductions were observed in gastric dose parameters in ABC-DIBH mode, including Dmax (46.60 vs 17.25, p < 0.001), D1cc (38.42 vs 9.60, p < 0.001), Dmean (4.10 vs 0.80, p < 0.001), V40Gy (0.50 vs 0.00, p < 0.001), V30Gy (6.30 vs 0.00, p < 0.001), V20Gy (20.80 vs 0.00, p < 0.001), V10Gy (51.10 vs 0.77, p < 0.001), and V5Gy (93.20 vs 9.60, p < 0.001). ABC-DIBH increased the distance between the stomach and the breast PTV when compared to FB, from 1.3 cm to 2.8 cm (p < 0.001). Physiologic decrease in stomach volume was not found from FB to ABC-DIBH (415.54 cm(3) vs 411.61 cm(3), p = 0.260). The stomach volume showed a positive correlation with V40Gy (r(2) = 0.289; p < 0.05), V30Gy (r(2) = 0.287; p < 0.05), V20Gy (r(2) = 0.343; p < 0.05), V10Gy (r(2) = 0.039; p < 0.001), V5Gy (r(2) = 0.439; p < 0.001), Dmax (r(2) = 0.269; p < 0.05) and D1cc (r(2) = 0.278; p < 0.05) in FB mode. While in ABC-DIBH mode, most stomach dosimetric parameters were not correlated with gastric volume.Conclusions: The implementation of ABC-DIBH in LSBCPs radiotherapy resulted in lower irradiation of the stomach. Larger stomach volume was associated with statistically significantly higher dose irradiation in FB mode. To reduce radiotherapy related side effects in FB mode, patients should be fast for at least 2 hours before the CT simulation and treatment.

Left-sided breast cancer radiotherapy stomach dose stomach volume ABC-DIBH

SCI

英语

通讯

Oncology

Oncology

WOS:001097581000001

TAYLOR & FRANCIS LTD

CLINICAL MEDICINE

Web of Science

1.Jinan Univ, Shenzhen Peoples Hosp, Dept Radiat Oncol, 2 Clin Med Coll, Guangzhou, Peoples R China
2.Southern Univ Sci & Technol, Affiliated Hosp 1, Shenzhen, Guangdong, Peoples R China
3.Ctr AIDS STD Control & Prevent, Sichuan Prov Ctr Dis Control & Prevent, Chengdu, Sichuan, Peoples R China

Piao, Ying,Chen, Hongtao,Yuan, Fengshun,et al. Active Breathing Coordinator reduces radiation dose to the stomach in patients with left breast cancer[J]. ACTA ONCOLOGICA,2023.

Piao, Ying.,Chen, Hongtao.,Yuan, Fengshun.,Fan, Juan.,Wu, Shihai.,...&Yang, Dong.(2023).Active Breathing Coordinator reduces radiation dose to the stomach in patients with left breast cancer.ACTA ONCOLOGICA.

Piao, Ying,et al."Active Breathing Coordinator reduces radiation dose to the stomach in patients with left breast cancer".ACTA ONCOLOGICA (2023).